LOX-1 in atherosclerosis and myocardial ischemia: biology, genetics, and modulation
NVK Pothineni, SK Karathanasis, Z Ding… - Journal of the American …, 2017 - jacc.org
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), one of the scavenger
receptors for oxidized low-density lipoprotein cholesterol (ox-LDL), plays a crucial role in the …
receptors for oxidized low-density lipoprotein cholesterol (ox-LDL), plays a crucial role in the …
LOX-1 the multifunctional receptor underlying cardiovascular dysfunction
S Ogura, A Kakino, Y Sato, Y Fujita, S Iwamoto… - Circulation …, 2009 - jstage.jst.go.jp
Oxidatively modified low-density lipoprotein (oxLDL) is implicated in the pathogenesis of
atherosclerosis. Endothelial dysfunction is the initial change in the vascular wall that induces …
atherosclerosis. Endothelial dysfunction is the initial change in the vascular wall that induces …
Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1): a critical player in the development of atherosclerosis and related disorders
JL Mehta, J Chen, PL Hermonat, F Romeo… - Cardiovascular …, 2006 - academic.oup.com
Abstract LOX-1, a lectin-like 52-kD receptor for oxidized low-density lipoproteins (ox-LDL), is
present primarily on endothelial cells. This receptor is upregulated by ox-LDL itself and by …
present primarily on endothelial cells. This receptor is upregulated by ox-LDL itself and by …
LOX-1 and atherosclerotic-related diseases
P Jin, S Cong - Clinica chimica acta, 2019 - Elsevier
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), a scavenger receptor of
oxidized low-density lipoprotein (ox-LDL) found in various cells, plays a crucial role in the …
oxidized low-density lipoprotein (ox-LDL) found in various cells, plays a crucial role in the …
Targeting LOX‐1 in atherosclerosis and vasculopathy: current knowledge and future perspectives
Abstract LOX‐1 (lectin‐like oxidized low‐density lipoprotein receptor‐1; also known as
OLR1) is the dominant receptor that recognizes and internalizes oxidized low‐density …
OLR1) is the dominant receptor that recognizes and internalizes oxidized low‐density …
The discovery of LOX-1, its ligands and clinical significance
R Yoshimoto, Y Fujita, A Kakino, S Iwamoto… - … drugs and therapy, 2011 - Springer
LOX-1 is an endothelial receptor for oxidized low-density lipoprotein (oxLDL), a key
molecule in the pathogenesis of atherosclerosis. The basal expression of LOX-1 is low but …
molecule in the pathogenesis of atherosclerosis. The basal expression of LOX-1 is low but …
LOX-1 and atherosclerosis: proof of concept in LOX-1–knockout mice
H Morawietz - Circulation research, 2007 - Am Heart Assoc
An increased plasma level of low-density lipoprotein (LDL) is a well-known risk factor for
endothelial dysfunction and atherosclerosis. 1 The proatherosclerotic potential of LDL may …
endothelial dysfunction and atherosclerosis. 1 The proatherosclerotic potential of LDL may …
LOX-1 in atherosclerosis: biological functions and pharmacological modifiers
Lectin-like oxidized LDL (oxLDL) receptor-1 (LOX-1, also known as OLR-1), is a class E
scavenger receptor that mediates the uptake of oxLDL by vascular cells. LOX-1 is involved …
scavenger receptor that mediates the uptake of oxLDL by vascular cells. LOX-1 is involved …
Role of LOX-1 (lectin-like oxidized low-density lipoprotein receptor 1) as a cardiovascular risk predictor: mechanistic insight and potential clinical use
J Barreto, SK Karathanasis, A Remaley… - … , and vascular biology, 2021 - Am Heart Assoc
Atherosclerosis, the underlying cause of cardiovascular disease (CVD), is a worldwide
cause of morbidity and mortality. Reducing ApoB-containing lipoproteins—chiefly, LDL (low …
cause of morbidity and mortality. Reducing ApoB-containing lipoproteins—chiefly, LDL (low …
Atherosclerosis and the lectin-like oxidized low-density lipoprotein scavenger receptor
RS Vohra, JE Murphy, JH Walker… - Trends in cardiovascular …, 2006 - Elsevier
The Lectin-like OXidized low-density lipoprotein scavenger receptor (LOX-1) is implicated in
vascular inflammation and atherosclerotic plaque initiation, progression, and destabilization …
vascular inflammation and atherosclerotic plaque initiation, progression, and destabilization …