Interactions between serotonin and dopamine in the control of impulsive choice in rats: therapeutic implications for impulse control disorders

CA Winstanley, DEH Theobald, JW Dalley… - …, 2005 - nature.com
Forebrain serotonergic lesions attenuate the ability of d-amphetamine to decrease
impulsivity in a delay-discounting paradigm, potentially through interactions between the …

Global 5-HT depletion attenuates the ability of amphetamine to decrease impulsive choice on a delay-discounting task in rats

CA Winstanley, JW Dalley, DEH Theobald… - …, 2003 - Springer
Rationale Psychomotor stimulant drugs such as methylphenidate and amphetamine
decrease impulsive behaviour in attention deficit hyperactivity disorder patients by unknown …

Dissociable effects of monoamine reuptake inhibitors on distinct forms of impulsive behavior in rats

PJJ Baarendse, LJMJ Vanderschuren - Psychopharmacology, 2012 - Springer
Rationale High levels of impulsivity are a core symptom of psychiatric disorders such as
ADHD, mania, personality disorders and drug addiction. The effectiveness of drugs targeting …

Critical involvement of dopaminergic neurotransmission in impulsive decision making

MM van Gaalen, R van Koten, ANM Schoffelmeer… - Biological …, 2006 - Elsevier
BACKGROUND: Impulsive decision making, apparent as intolerance for reinforcement
delay, is prominent in attention-deficit/hyperactivity disorder. Commonly prescribed for this …

Fractionating impulsivity: contrasting effects of central 5-HT depletion on different measures of impulsive behavior

CA Winstanley, JW Dalley, DEH Theobald… - …, 2004 - nature.com
Reducing levels of 5-HT in the central nervous system has been associated with increases
in impulsive behavior. However, the impulsivity construct describes a wide range of …

Impulsivity: a discussion of clinical and experimental findings

J Evenden - Journal of psychopharmacology, 1999 - journals.sagepub.com
Impulsivity can often be an important clinical problem in psychiatry and neurology. In
psychiatry, the manifestation of impulsive behaviour in syndromes such as personality …

Modulation of high impulsivity and attentional performance in rats by selective direct and indirect dopaminergic and noradrenergic receptor agonists

ABP Fernando, D Economidou, DE Theobald… - …, 2012 - Springer
Rationale Impulsivity is associated with a number of psychiatric disorders, most notably
attention deficit/hyperactivity disorder (ADHD). Drugs that augment catecholamine function …

Impulsive action and impulsive choice are mediated by distinct neuropharmacological substrates in rat

NE Paterson, C Wetzler, A Hackett… - International Journal of …, 2012 - academic.oup.com
Impulsivity is a heterogeneous construct according to clinical and preclinical behavioural
measures and there is some preliminary evidence indicating distinct neurobiological …

Neurobehavioral mechanisms of impulsivity: fronto-striatal systems and functional neurochemistry

JW Dalley, AC Mar, D Economidou… - Pharmacology …, 2008 - Elsevier
Impulsive acts and decisions are a part of everyday normal behavior. However, in its
pathological forms, impulsivity can be a debilitating disorder often associated with a number …

Limbic corticostriatal systems and delayed reinforcement

RN Cardinal, CA Winstanley… - Annals of the New …, 2004 - Wiley Online Library
Impulsive choice, one aspect of impulsivity, is characterized by an abnormally high
preference for small, immediate rewards over larger delayed rewards, and can be a feature …