Cytokine patterns in a prospective cohort of HIV-infected patients with cryptococcal meningitis following initiation of antifungal and antiretroviral therapy

DJ Mora, K Ferreira-Paim, LE Andrade-Silva… - PLoS …, 2017 - journals.plos.org
Cryptococcal meningitis (CM) is a life-threatening infection in HIV-infected patients,
especially in resource-limited settings. Cytokine patterns in the cerebrospinal fluid (CSF) …

Cytokine profiles at admission can be related to outcome in AIDS patients with cryptococcal meningitis

DJ Mora, LR Fortunato, LE Andrade-Silva… - PloS one, 2015 - journals.plos.org
Cryptococcal meningitis (CM) remains as common life-threatening AIDS-defining illness
mainly in resource-limited settings. Previous reports suggested that baseline cytokine …

Cerebrospinal fluid cytokine and chemokine patterns correlate with prognosis of HIV-uninfected cryptococcal meningitis: A prospective observational study

YK Jiang, RY Wang, LH Zhou, JH Cheng… - Frontiers in …, 2022 - frontiersin.org
The cerebrospinal fluid (CSF) immune responses in HIV-uninfected cryptococcal meningitis
(CM) have not been well studied. In this study, we aimed to explore the phenotype of CSF …

Cerebrospinal fluid cytokine profiles predict risk of early mortality and immune reconstitution inflammatory syndrome in HIV-associated cryptococcal meningitis

JN Jarvis, G Meintjes, T Bicanic, V Buffa… - PLoS …, 2015 - journals.plos.org
Understanding the host immune response during cryptococcal meningitis (CM) is of critical
importance for the development of immunomodulatory therapies. We profiled the …

A preliminary study on the characteristics of Th1/Th2 immune response in cerebrospinal fluid of AIDS patients with cryptococcal meningitis

A Li, W Zhu, J Yin, X Huang, L Sun, W Hua… - BMC Infectious …, 2021 - Springer
Abstract Background Cryptococcal Meningitis (CM) is a common opportunistic infection in
the late stage of acquired immunodeficiency syndrome (AIDS). Despite the wide use of …

Differences in cytokine and chemokine profiles in cerebrospinal fluid caused by the etiology of cryptococcal meningitis and tuberculous meningitis in HIV patients

L Xu, Y Xu, Y Zheng, X Peng, Z Yang… - Clinical & …, 2021 - academic.oup.com
The roles of cytokines and chemokines in HIV-associated cryptococcal meningitis (HCM)
and HIV-associated tuberculous meningitis (HTBM) are debatable. In sum, 34 HIV-infected …

The CSF Immune Response in HIV-1–Associated Cryptococcal Meningitis: Macrophage Activation, Correlates of Disease Severity, and Effect of Antiretroviral Therapy

JE Scriven, LM Graham, C Schutz… - JAIDS Journal of …, 2017 - journals.lww.com
Background: Immune modulation may improve outcome in HIV-associated cryptococcal
meningitis. Animal studies suggest alternatively activated macrophages are detrimental but …

Severe CSF immune cell alterations in cryptococcal meningitis gradually resolve during antifungal therapy

C Dambietz, M Heming, TJ Brix… - BMC neurology, 2024 - Springer
Cryptococcal meningitis (CM) is a severe fungal disease in immunocompromised patients
affecting the central nervous system (CNS). Host response and immunological alterations in …

Longitudinal Changes in CD4+, CD8+ T Cell Phenotype and Activation Marker Expression Following Antiretroviral Therapy Initiation among Patients with …

A Bayiyana, S Okurut, R Nabatanzi, G Zziwa… - Journal of Fungi, 2019 - mdpi.com
Despite improvement in the prognosis of HIV/AIDS (human immunodeficiency virus/acquired
immune deficiency syndrome) patients on antiretroviral therapy (ART), cryptococcal …

CSF Cytokines and Chemokines Involved in Cytotoxic Cell Function and Risk of Acute 14-Day Mortality in Persons with Advanced HIV and Cryptococcal Meningitis

EC Okafor, L Mukaremera, KH Hullsiek… - The Journal of …, 2024 - academic.oup.com
Background Despite availability of HIV treatment globally, cryptococcal meningitis continues
to cause considerable morbidity and mortality. The role of the immune response in acute …