Characterization of the potential allergenicity of irradiated bovine α-lactalbumin in a BALB/c mouse model

X Meng, X Li, J Gao, H Chen - Food and Chemical Toxicology, 2016 - Elsevier
Bovine α-lactalbumin (ALA) is a known food allergen present in milk to induce anaphylaxis.
A previous study demonstrated that irradiated ALA (iALA) decreased the IgE-binding …

Potential allergenicity response to structural modification of irradiated bovine α-lactalbumin

X Meng, X Li, X Wang, J Gao, H Yang, H Chen - Food & function, 2016 - pubs.rsc.org
Bovine α-lactalbumin (α-La) is a major food allergen found in milk and is characterized by
high conformational stability because of its four disulfide bridges and being calcium bound …

A BALB/c mouse model for assessing the potential allergenicity of proteins: comparison of allergen dose, sensitization frequency, timepoint and sex

C Chen, N Sun, Y Li, X Jia - Food and chemical toxicology, 2013 - Elsevier
The present study was to investigate the possibility of using the BALB/c mouse as an animal
model for assessing the potential allergenicity of proteins. Specific IgE and IgG1 against …

Reducing the allergenicity of α-lactalbumin after lipid peroxidation

L Lv, K He, F Sun, X Lin, L Ye, Y Lyu, L Liu… - Journal of Agricultural …, 2021 - ACS Publications
This study analyzed the effect of lipid peroxidation using 2, 2′-azobis (2-amidinopropane)
dihydrochloride (AAPH) and acrolein on the in vitro and in vivo allergenicity of α-lactalbumin …

Potential allergenicity assessment after bovine apo‐α‐lactalbumin binding to calcium ion

M Huang, X Li, P Tong, J Gao, J Yuan… - Journal of Food …, 2020 - Wiley Online Library
Bovine α‐lactalbumin (α‐LA) is recognized as a major milk allergen. Generally, α‐LA in the
natural state combines with a calcium ion, however, some studies have shown that calcium …

Evaluation of the antigenicity of hydrolyzed cow's milk protein formulas using the mouse basophil activation test

H Iwamoto, T Matsubara, Y Nakazato, K Namba… - Toxicology Letters, 2016 - Elsevier
Hypoallergenic infant formulas are widely used for infants with cow's milk allergy. The aim of
this study was to assess the utility of the mouse basophil activation test (BAT) in the …

The mechanism of the reduction in allergenic reactivity of bovine α-lactalbumin induced by glycation, phosphorylation and acetylation

J Liu, W Chen, Y Shao, J Zhang, Z Tu - Food chemistry, 2020 - Elsevier
Bovine α-lactalbumin (α-Lac) allergy is a common health problem. This study assesses the
allergenic reactivity and the structural properties of α-Lac after protein modification …

[HTML][HTML] Structure and allergenicity of α-lactalbumin: effects of ultrasonic prior to glycation and subsequent phosphorylation

W Chen, Q Chen, H Zhou, Y Shao, Y Wang… - Food Science and …, 2023 - Elsevier
Bovine α-lactalbumin (BLA) induced severe cow's milk allergy. In this study, a novel strategy
combining ultrasonication, performed before glycation, and phosphorylation was proposed …

[PDF][PDF] A model of intestinal anaphylaxis in whey sensitized Balb/c mice

N Hanane, K Hanane, K Omar… - American Journal of …, 2009 - academia.edu
Problem statement: Cow's Milk Allergy (CMA) is a common disease in childhood.
Pathophysiological mechanisms involved in gastrointestinal symptoms are relatively poorly …

Immunostimulatory potential of β-lactoglobulin preparations: Effects caused by endotoxin contamination

S Brix, L Bovetto, R Fritsché, V Barkholt… - Journal of Allergy and …, 2003 - Elsevier
BACKGROUND: The immunomodulating potential residing in cow's milk proteins is currently
receiving increasing attention because of growing interest in functional foods and the …