Sonic Hedgehog (Shh) signaling by the polarizing region, at the posterior of the vertebrate
limb bud, is pivotal in determining digit number and identity. Shh establishes a gradient of …

Sonic hedgehog (Shh) is a key signal in establishing different digit fates along the anterior–
posterior axis of the vertebrate limb bud. Although the anterior digits appear to be specified …

Anterior–posterior (A/P) limb patterning in vertebrates is determined by the counteraction
between the Sonic Hedgehog (Shh) and the Gli3 transcription factor. Shh exerts its effect on …

Sonic hedgehog (Shh) signaling is essential for the anterior-posterior (AP) patterning of the
embryonic limb bud. An additional role for Shh has now been identified in the mouse and …

Limb patterning by Sonic hedgehog (Shh), via either graded spatial or temporal signal
integration, is a paradigm for" morphogen" function, yet how Shh instructs distinct digit …

In the vertebrate limb, the posteriorly located zone of polarizing activity (ZPA) regulates digit
identity through the morphogen Sonic Hedgehog (Shh). By genetically marking Shh …

Anteroposterior polarity in the vertebrate limb is thought to be regulated in response to
signals derived from a specialized region of distal posterior mesenchyme, the zone of …

Sonic hedgehog (Shh), which regulates proliferation in many contexts, functions as a limb
morphogen to specify a distinct pattern of digits. How Shh's effects on cell number relate to …

Abstract Among John Saunders' many seminal contributions to developmental biology, his
discovery of the limb 'zone of polarizing activity'(ZPA) is arguably one of the most memorable …

It has been proposed that digit identity in chick limb bud is specified in a dose-dependent
fashion by a long-range morphogen, produced by the polarising region. One candidate is …