Integration host factor (IHF) is a protein that binds to the H′ site of bacteriophage λ with
sequence specificity. Genetic experiments implicated amino acid residue Glu 44 of the β …

The integration host factor (IHF) is a prominent example of indirect readout as it imposes one
of the strongest bends on relaxed linear DNA. However, the relation between IHF and …

Integration host factor (IHF) is required in lambda site‐specific recombination to deform the
DNA substrates into conformations active for recombination. HU, a homolog of IHF, can also …

How DNA-bending proteins recognize their specific sites on DNA remains elusive,
particularly for proteins that use indirect readout, which relies on sequence-dependent …

Integration of human immunodeficiency virus type 1 cDNA into a target DNA can be strongly
influenced by the conformation of the target. For example, integration in vitro is sometimes …

The integration of retroviral DNA by the viral integrase (IN) into the host genome occurs via
assembled preintegration complexes (PIC). We investigated this assembly process using …

A tetramer of HIV-1 integrase (IN) stably associates with the viral DNA ends to form a fully
functional concerted integration intermediate. LEDGF/p75, a key cellular binding partner of …

Double Holliday junctions (dHJS) are important intermediates of homologous
recombination. The separate junctions can each be cleaved by DNA structure-selective …

The Holliday junction-resolving enzyme Hjc is conserved in the archaea and probably plays
a role analogous to that ofEscherichia coli RuvC in the pathway of homologous …

Hin, a member of the serine family of site-specific recombinases, regulates gene expression
by inverting a DNA segment. DNA inversion requires assembly of an invertasome complex …