The appropriateness of the recommended L-thyroxine dose (10-15 μg/kg/day) for the
treatment of congenital hypothyroidism has been questioned because of the risk of …

Objectives: To determine the optimal initial treatment dose of L-thyroxine in congenital
hypothyroidism (CH) by evaluating the time course of rise of thyroxine (T4) and free T4 …

Background: Current guidelines recommend an initial L-thyroxine (L-T4) dose of 10–15
μg/kg/day for the treatment of congenital hypothyroidism (CH). We analyzed our data for the …

We evaluated the longitudinal response in 43 infants with congenital primary hypothyroidism
during the first year of l-thyroxine therapy. Diagnosis was confirmed by serum thyroid …

The adequate l-thyroxine dosage for the initial treatment of infants with congenital
hypothyroidism is a subject of controversy. Some recommend higher dosages (> 10 …

Objective: To assess factors influencing thyroxine (T4 levels 1 month after initiating
replacement therapy for congenital primary hypothyroidism. Methodology: A retrospective …

Objective: To study the effects of initial and concurrent dose levels of L-thyroxine on ability
and behavior in children with congenital hypothyroidism. Methods: An existing database …

Neonatal thyroid screening programs were first im-plemented in the mid-to late 1970s to
detect congenital hypothyroidism (CH) as soon after birth as possible and begin therapy …

The symptoms and signs develop over the ensuing weeks of extra-uterine life. Only in the
severest cases are subtle signs of hypothy-roidism present at birth, such as prolonged …

Early detection by newborn screening and appropriate L-thyroxine treatment leads to normal
or near-normal neurocognitive outcome in infants with congenital hypothyroidism. Many …