Cloning and transgenesis in mammals: Implications for xenotransplantation

JA Piedrahita, B Mir - American Journal of Transplantation, 2004 - Wiley Online Library
Availability of suitable organs for transplantation remains of major concern and projections
indicate that the problem will continue to increase. Therefore, alternatives to the use of …

Production of transgenic and knockout pigs by somatic cell nuclear transfer

AM Giraldo, S Ball, KR Bondioli - Xenotransplantation: Methods and …, 2012 - Springer
Xenotransplantation is one alternative to transplantation of human organs which has been
investigated. It is generally accepted that the pig represents the most logical choice of …

Potential use of genetically modified pigs as organ donors for transplantation into humans

JS Logan, A Sharma - Clinical and experimental …, 1999 - Wiley Online Library
Transplantation is currently viewed as a successful treatment for end‐stage organ failure. Its
more widespread use is severely limited by a shortage of human organ donors. This has …

Genetically modified pigs as donors of cells, tissues, and organs for xenotransplantation

E Wolf, E Kemter, N Klymiuk, B Reichart - Animal Frontiers, 2019 - academic.oup.com
Genetically modified pigs as donors of cells, tissues, and organs for xenotransplantation |
Animal Frontiers | Oxford Academic Skip to Main Content Advertisement Oxford Academic …

Xenotransplantation: progress along paths uncertain from models to application

JL Platt, M Cascalho, JA Piedrahita - ILAR journal, 2018 - academic.oup.com
For more than a century, transplantation of tissues and organs from animals into man,
xenotransplantation, has been viewed as a potential way to treat disease. Ironically, interest …

Current status and perspectives for the generation of transgenic pigs for xenotransplantation.

H Niemann - Annals of transplantation, 2001 - europepmc.org
Xenotransplantation implies transplantation of organs between discordant, eg non-related
species. This procedure usually is associated with a hyperacute rejection response (HAR) …

Xeno-organ donor pigs with multiple genetic modifications–the more the better?

E Kemter, A Schnieke, K Fischer, PJ Cowan… - Current Opinion in …, 2020 - Elsevier
The number of donated human organs and tissues for patients with terminal organ failure
falls far short of the need. Alternative sources, such as organs and tissues from animals, are …

Targeted genetic modification: xenotransplantation and beyond

RS Prather - Cloning and stem cells, 2007 - liebertpub.com
THE 10TH ANNIVERSARY of the report of the first animal cloned from an adult cell (Wilmut
et al., 1997) is an excellent time to look back, and to look forward. The ability to clone …

Genetic modification of pigs as organ donors for xenotransplantation

N Klymiuk, B Aigner, G Brem… - Molecular Reproduction …, 2010 - Wiley Online Library
Transgenic pigs are promising donor organisms for xenotransplantation as they share many
anatomical and physiological characteristics with humans. The most profound barrier to pig …

A method for producing cloned pigs by using somatic cells as donors

L Lai, RS Prather - Germ Cell Protocols: Volume 2: Molecular Embryo …, 2004 - Springer
Nuclear transfer (NT) is a procedure by which genetically identical individuals can be
created. The applications of these NT techniques will be in agriculture, biomedicine, and …