Xenotransplantation of solid organs in the pig-to-primate model

B Ekser, P Rigotti, B Gridelli, DKC Cooper - Transplant immunology, 2009 - Elsevier
Xenotransplantation using pig organs could solve the significant increasing shortage of
donor organs for allotransplantation. In the last two decades, major progress has been made …

The resurgent landscape of xenotransplantation of pig organs in nonhuman primates

X Zhang, Q Wang, J Zhao, X Li, W Peng, Z Yang… - Science China Life …, 2021 - Springer
Organ shortage is a major bottleneck in allotransplantation and causes many wait-listed
patients to die or become too sick for transplantation. Genetically engineered pigs have …

[HTML][HTML] The immense potential of xenotransplantation in surgery

DKC Cooper, D Ayares - International Journal of Surgery, 2011 - Elsevier
There is a limited availability of deceased human organs and cells for the purposes of
clinical transplantation. Genetically-engineered pigs may provide an alternative source …

Xenotransplantation: problems and prospects

FH Bach - Annual review of medicine, 1998 - annualreviews.org
Research in xenotransplantation has increased enormously in the last eight years. As the
shortage of allogeneic organs has intensified, the possibility of using organs from pigs has …

Xenografts are an achievable breakthrough

JM Alisky - Medical hypotheses, 2004 - Elsevier
The objective of this communication is to show that pig-to-human organ transplantation
could be feasible through genetic engineering. By introducing into donor pigs several …

Potential benefits and risks of clinical xenotransplantation

DKC Cooper, D Ayares - Transplant Research and Risk …, 2012 - Taylor & Francis
The transplantation of organs and cells from pigs into humans could overcome the critical
and continuing problem of the lack of availability of deceased human organs and cells for …

Animal organs for human transplantation: how close are we?

MF Levy - Baylor University Medical Center Proceedings, 2000 - Taylor & Francis
Solid organ transplantation has been, by most measures, a phenomenal success.
Nonetheless, the field is plagued by extreme shortages of available organs from a very …

Gene editing, gene therapy, and cell xenotransplantation: cell transplantation across species

NI Mourad, P Gianello - Current transplantation reports, 2017 - Springer
Abstract Purpose of Review Cell xenotransplantation has the potential to provide a safe,
ethically acceptable, unlimited source for cell replacement therapies. This review focuses on …

The case for xenotransplantation

DKC Cooper - Clinical transplantation, 2015 - Wiley Online Library
The availability of organs and cells from deceased humans for transplantation is not meeting
the demand. Xenotransplantation, specifically the transplantation of organs and cells from …

Xenotransplantation in China: present status

Y Wang, T Lei, L Wei, S Du, L Girani… - …, 2019 - Wiley Online Library
The main obstacle to organ transplantation is the shortage of organs from deceased
individuals. Especially in China, the ratio of patients on the waiting list versus the transplant …