Genetically engineered pigs are now available for xenotransplantation in which all three
known carbohydrate xenoantigens, against which humans have natural antibodies, have …

This review aims to show and illustrate the history, current, ethical considerations, and
limitations concerning xenotransplantation. Due to the current shortage of available donor …

Animal models, particularly pigs, have come to play an important role in translational
biomedical research. There have been many pig models with genetically modifications via …

Additive transgenesis by pronuclear injection of the mouse zygote has been in use for more
than 20 yr and gene targeting in mouse embryonic stem cells for almost as long. Together …

The production of animals by somatic cell nuclear transfer (SCNT) is inefficient, with
approximately 2% of micromanipulated oocytes going to term and resulting in live births …

Xenotransplantation was proposed a long time ago as a possible solution to the world-wide
shortage of human organs. For years, researchers in this field have almost exclusively …

The birth of the first nuclear transfer-derived cloned piglet resulted from the transfer of a
nucleus from a 4-cell stage embryo to an enucleated oocyte. Although biotechnological …

The first transgenic livestock were produced in 1985 by microinjection of foreign DNA into
zygotic pronuclei. This was the method of choice for more than 20 years, but more efficient …

The clinical applicability of porcine xenotransplantation—a long-investigated alternative to
the scarce availability of human organs for patients with organ failure—is limited by …

The extreme shortage of human donor organs for treatment of patients with end-stage organ
failures is well known. Xenotransplantation, which might provide unlimited organ supply, is a …