Despite extensive research, pro-angiogenic drugs have failed to translate clinically, and
therapeutic angiogenesis, which has potential in the treatment of various cardiovascular …

A functional microvascular system is imperative to build and maintain healthy tissue.
Impaired microvasculature results in ischemia, thereby limiting the tissue's intrinsic …

The vasculature is a key component of the tissue microenvironment. Traditionally known for
its role in providing nutrients and oxygen to surrounding cells, the vasculature is now also …

One of the most arduous challenges in tissue engineering is neovascularization, without
which there is a lack of nutrients delivered to a target tissue. Angiogenesis should be …

From microscaled capillaries to millimeter‐sized vessels, human vasculature spans multiple
scales and cell types. The convergence of bioengineering, materials science, and stem cell …

The ability to understand and regulate human vasculature development and differentiation
has the potential to benefit patients suffering from a variety of ailments, including …

Enabling angiogenesis is critical for the success of tissue repair therapies and the fate of
tissue-engineered constructs. Although many biochemical signaling molecules have been …

The field of tissue engineering has turned towards biomimicry to solve the problem of tissue
oxygenation and nutrient/waste exchange through the development of vasculature …

Blood vessel growth plays a key role in regenerative medicine, both to restore blood supply
to ischemic tissues and to ensure rapid vascularization of clinical-size tissue-engineered …

Angiogenesis is a complex morphogenetic process that involves intimate interactions
between multicellular endothelial structures and their extracellular milieu. In vitro models of …