The major events of the cell division cycle are triggered by periodic changes in the activity of
cyclin-dependent protein kinases (CDKs). In mammals, the members of the CDK family …

The division cycle of eukaryotic cells is regulated by a family of protein kinases known as the
cyclin-dependent kinases (CDKs) 1, 2. The sequential activation of individual members of …

Abstract CYCLIN-dependent kinase 5 (Cdk5) was originally isolated through its structural
homology to human Cdc21, a key regulator of cell-cycle progression2–6. In tissue samples …

As key regulators of the cell cycle, the cyclin-dependent kinases must be tightly regulated by
extra-and intracellular signals. The activity of cyclin-dependent kinases is controlled by four …

Unicellular organisms such as yeasts require a single cyclin-dependent kinase, Cdk1, to
drive cell division. In contrast, mammalian cells are thought to require the sequential …

We have analyzed the cell cycle regulation of human cyclin-dependent kinase 2 (CDK2), a
protein closely related to the cell cycle-regulatory protein kinase CDC2. We find that CDK2 …

The events of cell reproduction are governed by oscillations in the activities of cyclin-
dependent kinases (Cdks). Cdks control the cell cycle by catalysing the transfer of …

Critical cell cycle transitions are controlled by the coordinate actions of the p34cdc2 protein
kinase and its regulatory subunits, cyclins. Recently we identified another human p34 …

p33cdk2 is a serine-threonine protein kinase that associates with cyclins A, D, and E and
has been implicated in the control of the G1/S transition in mammalian cells. Recent …

Cyclin-dependent kinases (CDKs) are protein kinases involved in critical cellular processes,
such as cell cycle or transcription, whose activity requires association with specific cyclin …