Background Oocyte maturation arrest and early embryonic arrest are important reproductive
phenotypes resulting in female infertility and cause the recurrent failure of assisted …

Idiopathic or “unexplained” infertility represents as many as 30% of infertility cases
worldwide. Conception, implantation, and term delivery of developmentally healthy infants …

STUDY QUESTION Are there more de novo mutations (DNMs) present in the genomes of
children born through medical assisted reproduction (MAR) compared to spontaneously …

Genetic testing is becoming increasingly required at almost every stage of failed female
reproduction/infertility. Nonetheless, clinical evidence for the majority of identified gene …

Infertility is a complex multifactorial disease that affects up to 10% of couples across the
world. However, many mechanisms of infertility remain unclear due to the lack of studies …

BACKGROUND Infertility is a major issue in human reproductive health, affecting an
estimated 15% of couples worldwide. Infertility can result from disorders of sex development …

BACKGROUND Infertility and pregnancy loss are longstanding problems. Successful
fertilization and high-quality embryos are prerequisites for an ongoing pregnancy. Studies …

There exist some patients who face recurrent total fertilization failure during assisted
reproduction treatment, but the pathological mechanism underlying is elusive. Here, by …

Primary ovarian insufficiency (POI) is one of the major causes of female infertility associated
with the premature loss of ovarian function in about 3.7% of women before the age of 40 …

Research question Can a methodology be developed for case selection and whole-exome
sequencing (WES) analysis of women who are infertile owing to recurrent oocyte maturation …