Adoptive cell therapy with tumor-targeted T cells is a promising approach to cancer therapy.
Enhanced clinical outcome using this approach requires conditioning regimens with total …

Adoptive T cell transfer for cancer, chronic infection, and autoimmunity is an emerging field
that shows promise in recent trials. Using the principles of synthetic biology, advances in cell …

Antitumor T cells are subject to multiple mechanisms of negative regulation,,. Recent
findings that innate lymphoid cells (ILCs) regulate adaptive T cell responses,, led us to …

Transplantation of hematopoietic cells from a healthy individual (allogeneic hematopoietic
cell transplantation (allo-HCT)) demonstrates that adoptive immunotherapy can cure blood …

Decades of work have aimed to genetically reprogram T cells for therapeutic purposes,
using recombinant viral vectors, which do not target transgenes to specific genomic sites …

Adoptive cell therapies using genetically engineered T cell receptor or chimeric antigen
receptor T cells are emerging forms of immunotherapy that redirect T cells to specifically …

Recently activated, but not resting, CD4+ T cells express CD154, providing costimulatory
signals to B cells and antigen-presenting cells (APCs). Therefore, de novo CD154 …

Interleukin-2 (IL-2), which is a growth factor for T lymphocytes, can also sometimes be
inhibitory. Thus, the proliferation of CD8+ T cells in vivo is increased after the injection of a …

A hallmark of adaptive immunity is the generation of memory T cells that confer long-lived,
antigen-specific protection against repeat challenges by pathogens,,,,. Understanding the …

Adoptive transfer of antigen-specific cytotoxic T lymphocytes (CTLs) can induce objective
clinical responses in patients with malignant diseases. The option of providing a proliferative …