Background Atopic dermatitis (AD) is characterized by intense pruritis and is a common
childhood inflammatory disease. Many factors are known to affect AD development …

Wound healing in a pre-existing Th2-dominated skin milieu was assessed by using an
epidermal specific interleukin-4 (IL-4) transgenic (Tg) mouse model, which develops a …

Background Atopic dermatitis (AD) is associated with epidermal barrier defects, dysbiosis,
and skin injury caused by scratching. In particular, the barrier-defective epidermis in patients …

Despite the important role for epidermal growth factor (EGF) in epithelial homeostasis and
wound healing, it has not been investigated in atopic dermatitis (AD). We used AD animal …

Background Epidermal barrier dysfunction has been recognized as a critical factor in the
initiation and exacerbation of skin inflammation, particularly in patients with atopic dermatitis …

Atopic dermatitis (AD) is a common chronic inflammatory skin disease. Although the
pathogenesis of AD is not fully understood, we and others have shown that IL-4 plays a key …

IL-4 promotes the development of Th2 cells and allergic inflammation. In atopic dermatitis
lesions, IL-4 decreases the expression of multiple genes associated with innate defense …

In the first approach, monolayer keratinocytes and skin samples were stimulated with IL-33
or IL-4 to analyze FLG mRNA expression (see additional information in the Methods section …

Background Atopic dermatitis skin lesions demonstrate increased expression of IL-25 by
keratinocytes and increased numbers of type 2 innate lymphoid cells (ILC2s) that express …

Skin fibrotic remodeling is a major feature in human atopic dermatitis (AD). Inflammation and
tissue fibrosis are common consequences of Th2 responses. Elevated IL-13 and thymic …