Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

New therapeutic approaches for the treatment of obesity | Science Translational Medicine
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Obesity represents a major public health problem with a prevalence increasing at an
alarming rate worldwide. Continuous intensive efforts to elucidate the complex …

The worldwide prevalence of obesity is increasing at an alarming rate, with major adverse
consequences for human health. This" obesity epidemic" is paralleled by a rapid and …

Obesity is a complex multifactorial disease that accumulated excess body fat leads to
negative effects on health. Obesity continues to accelerate resulting in an unprecedented …

Regulation of body weight is organized by distributed brain circuits that use a variety of
neuropeptides and transmitters, and that are responsive to endocrine and metabolic signals …

This article reviews novel developments in the behavioral and pharmacologic treatment of
obesity and explores the potential contribution of genomics research to weight control. A …

Recent insights into the pathophysiologic underlying mechanisms of obesity have led to the
discovery of several promising drug targets and novel therapeutic strategies to address the …

Obesity is an increasingly prevalent and important health problem. Although treatment is
available, the long-term maintenance of medically significant weight loss (5 to 10 percent of …

There is a huge void in the current pharmacological treatment options for obesity. This gap is
surprising given the high prevalence and associated costs of obesity. Many factors have …