Thymoquinone‐induced antitumor and apoptosis in human lung adenocarcinoma cells

S Samarghandian, M Azimi‐Nezhad… - Journal of cellular …, 2019 - Wiley Online Library
Background Lung cancer has been associated with the highest cancer‐associated mortality
rate in the world. Chemotherapeutic management of cancer necessitates introducing new …

Anti-cancer effects of thymoquinone in mouse neuroblastoma (Neuro-2a) cells through caspase-3 activation with down-regulation of XIAP

A Paramasivam, S Sambantham, J Shabnam… - Toxicology letters, 2012 - Elsevier
Thymoquinone (TQ) is a bioactive component derived from the medicinal plant Nigella
sativa. Recent studies reported that TQ exhibited cytotoxic effects in several cancer cell …

Thymoquinone inhibits proliferation and invasion of human nonsmall-cell lung cancer cells via ERK pathway

J Yang, X Kuang, P Lv, X Yan - Tumor Biology, 2015 - Springer
Thymoquinone (TQ) is the primary bioactive component of Nigella sativa Linn seed oil and
used as anti-inflammatory, anti-oxidant, and anti-neoplastic agent. Previous studies have …

Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo

SH Jafri, J Glass, R Shi, S Zhang, M Prince… - Journal of Experimental …, 2010 - Springer
Background Thymoquinone (TQ) is a compound extracted from Black Caraway seeds of
Nigella Sativa and is active against various cancers. Cisplatin (CDDP) is the most active …

Anticancer activity of thymoquinone in breast cancer cells: possible involvement of PPAR-γ pathway

CC Woo, SY Loo, V Gee, CW Yap, G Sethi… - Biochemical …, 2011 - Elsevier
Thymoquinone (TQ), an active ingredient of Nigella sativa, has been reported to exhibit anti-
oxidant, anti-inflammatory and anti-tumor activities through mechanism (s) that is not fully …

Thymoquinone from Nigella sativa was more potent than cisplatin in eliminating of SiHa cells via apoptosis with down-regulation of Bcl-2 protein

WK Ng, LS Yazan, M Ismail - Toxicology in vitro, 2011 - Elsevier
Thymoquinone (TQ), the active constituent of Nigella sativa or black cumin exhibited
cytotoxic effects in several cancer cell lines. In this study, the cytotoxicity of TQ in human …

[HTML][HTML] Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy

YK Mahmoud, HMA Abdelrazek - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Recently, there is growing interest in the natural bioactive components having anticancer
activity. Thymoquinone (TQ), the principle active constituent of black seed (Nigella sativa) …

Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism

H Gali-Muhtasib, M Diab-Assaf… - International …, 2004 - spandidos-publications.com
For centuries, the black seed (Nigella sativa) herb and oil have been used in Asia, Middle
East and Africa to promote health and fight disease. Thymoquinone (TQ), the most abundant …

Thymoquinone anticancer discovery: possible mechanisms

AH El-Far - Current drug discovery technologies, 2015 - ingentaconnect.com
Medicinal plants are known for their many advantages, including the ability to treat diseases
such as cancer. Nigella sativa and its active constituent thymoquinone (TQ) have long been …

Thymoquinone induces apoptosis and increase ROS in ovarian cancer cell line

MME Taha, BY Sheikh, LZA Salim… - Cellular and …, 2016 - mail.cellmolbiol.org
Nigella sativa is also known for its properties as a traditional herbal healing for many
ailments. In this study, the anticancer properties of thyomquinone (TQ), the active ingredient …