Articular adipose tissue is a ubiquitous component of human joints, but its local functions are
largely unknown. Because recent studies revealed several links between adipose tissue …

Metabolic syndrome (MetS) represents a cluster of metabolic and cardiovascular
complications, including obesity and visceral adiposity, insulin resistance, dyslipidemia …

Musculoskeletal pathologies (MSPs) such as osteoarthritis (OA) and osteoporosis (OP), are
a set of disorders that cause severe pain, motion difficulties, and even permanent disability …

Adiponectin is a protein hormone secreted predominantly by differentiated adipocytes and is
involved in energy homeostasis. Adiponectin expression is significantly high in the synovial …

Obesity is considered a major risk factor for the development and progression of knee
osteoarthritis (OA). Apart from the mechanical effect of obesity via increase in mechanical …

Adiponectin, the most prevalent adipo-cytokine in plasma plays critical metabolic and anti-
inflammatory roles is fast emerging as an important molecular target for the treatment of …

The growing burden of obesity and osteoporosis is a major public health concern. Emerging
evidence of the role of adipokines on bone metabolism has led to the discovery of novel …

Objective Rheumatoid arthritis (RA) is associated with increased production of adipokines,
which are cytokine‐like mediators that are produced mainly in adipose tissue but also in …

Rheumatoid arthritis is a chronic autoimmune disease affecting typically synovial joints and
leading to progressive articular damage, disability, and reduced quality of life. Despite better …

Introduction Increasing evidence support the regulatory role of leptin in osteoarthritis (OA).
As high circulating concentrations of leptin disrupt the physiological function of the adipokine …