Tissue engineering and regenerative medicine have come a long way in recent decades,
but the lack of functioning vasculature is still a major obstacle preventing the development of …

The ability of generate new microvessels in desired numbers and at desired locations has
been a long-sought goal in vascular medicine, engineering, and biology. Historically, the …

Vascularization is one of the great challenges that tissue engineering faces in order to
achieve sizeable tissue and organ substitutes that contain living cells. There are instances …

From microscaled capillaries to millimeter‐sized vessels, human vasculature spans multiple
scales and cell types. The convergence of bioengineering, materials science, and stem cell …

Vascularization is a major hurdle in complex tissue and organ engineering. Tissues greater
than 200 μm in diameter cannot rely on simple diffusion to obtain nutrients and remove …

Vascular tissue engineering has significant potential to make a major impact on a wide array
of clinical problems. Continued progress in understanding basic vascular biology will be …

Only a few engineered tissues—skin, cartilage, bladder—have achieved clinical success,
and biomaterials designed to replace more complex organs are still far from commercial …

Microvessels, including arterioles, capillaries, and venules, play an important role in
regulating blood flow, enabling nutrient and waste exchange, and facilitating immune …

Functional and perfusable vascular network formation is critical to ensure the long-term
survival and functionality of engineered tissues after their transplantation. Although several …

Recent advances in medicine and healthcare allow people to live longer, increasing the
need for the number of organ transplants. However, the number of organ donors has not …