Objective To investigate the effect of high fat diet-induced insulin resistance on autophagy
markers in the liver and skeletal muscle of mice in the fasted state and following an oral …

Background Autophagy maintains metabolic homeostasis of muscles, and its impairment
may cause muscle dysfunction. Exercise can improve muscle dysfunction induced by long …

Aims We conducted a meta-analysis to investigate whether diabetes induced by a high-fat
diet (HFD) has the potential to alter the process of autophagy in the murine liver. Methods A …

Exercise training has been demonstrated as an effective therapy for insulin resistance (IR) to
relieve skeletal muscle metabolic disorders. Physiologic protective autophagy was found …

Autophagy is a complex degradation pathway responsible for clearing damaged and
dysfunctional organelles. High-fat-diet–induced obesity has been shown to alter autophagy …

Skeletal muscle autophagy is suppressed by insulin, but it is not clear if such suppression is
altered with insulin resistance. We investigated if the inhibitory action of insulin on …

Aims Studies have observed changes in autophagic flux in the adipose tissue of type 2
diabetes patients with obesity. However, the role of autophagy in obesity-induced insulin …

Aims/hypothesis Autophagy is a catabolic process that maintains cellular homeostasis by
degradation of protein aggregates and selective removal of damaged organelles, eg …

This case-control study was designed to investigate the gene expression profile in skeletal
muscle from severely insulin resistant patients with long-standing type 2 diabetes (T2D), and …

Activation of autophagy in skeletal muscle has been reported in response to endurance
exercise and food deprivation independently. The purpose of this study was to evaluate …