Lack of brain serotonin affects postnatal development and serotonergic neuronal circuitry formation

S Migliarini, G Pacini, B Pelosi, G Lunardi… - Molecular …, 2013 - nature.com
Despite increasing evidence suggests that serotonin (5-HT) can influence neurogenesis,
neuronal migration and circuitry formation, the precise role of 5-HT on central nervous …

Genetic and early environmental influences on the serotonin system: consequences for brain development and risk for psychopathology

L Booij, RE Tremblay, M Szyf, C Benkelfat - Journal of psychiatry and …, 2015 - jpn.ca
Background: Despite more than 60 years of research in the role of serotonin (5-HT) in
psychopathology, many questions still remain. From a developmental perspective, studies …

Excess of serotonin affects embryonic interneuron migration through activation of the serotonin receptor 6

O Riccio, G Potter, C Walzer, P Vallet, G Szabó… - Molecular …, 2009 - nature.com
The discovery that a common polymorphism (5-HTTLPR, short variant) in the human
serotonin transporter gene (SLC6A4) can influence personality traits and increase the risk …

[HTML][HTML] Impacts of Brain Serotonin Deficiency following Tph2 Inactivation on Development and Raphe Neuron Serotonergic Specification

L Gutknecht, N Araragi, S Merker, J Waider… - 2012 - journals.plos.org
Brain serotonin (5-HT) is implicated in a wide range of functions from basic physiological
mechanisms to complex behaviors, including neuropsychiatric conditions, as well as in …

[HTML][HTML] Abnormal serotonin levels during perinatal development lead to behavioral deficits in adulthood

R Shah, E Courtiol, FX Castellanos… - Frontiers in behavioral …, 2018 - frontiersin.org
Serotonin (5-HT) is one of the best-studied modulatory neurotransmitters with ubiquitous
presynaptic release and postsynaptic reception. 5-HT has been implicated in a wide variety …

Serotonergic neurotransmission manipulation for the understanding of brain development and function: Learning from Tph2 genetic models

M Pratelli, M Pasqualetti - Biochimie, 2019 - Elsevier
Abstract Serotonin (5-hydroxytriptamine; 5-HT) is a fascinating neurotransmitter that thanks
to an extensive axonal network is released throughout the entire central nervous system …

The serotonin–BDNF duo: Developmental implications for the vulnerability to psychopathology

JR Homberg, R Molteni, F Calabrese… - … & Biobehavioral Reviews, 2014 - Elsevier
Abstract Serotonin (5-HT) and brain-derived neurotrophin factor (BDNF) are known to
modulate behavioral responses to stress and to mediate the therapeutic efficacy of …

[HTML][HTML] Serotonin homeostasis and serotonin receptors as actors of cortical construction: special attention to the 5-HT3A and 5-HT6 receptor subtypes

T Vitalis, MS Ansorge, AG Dayer - Frontiers in cellular neuroscience, 2013 - frontiersin.org
Cortical circuits control higher-order cognitive processes and their function is highly
dependent on their structure that emerges during development. The construction of cortical …

[HTML][HTML] Refining the role of 5-HT in postnatal development of brain circuits

A Teissier, M Soiza-Reilly, P Gaspar - Frontiers in cellular …, 2017 - frontiersin.org
Changing serotonin (5-hydroxytryptamine, 5-HT) brain levels during critical periods in
development has long-lasting effects on brain function, particularly on later …

[HTML][HTML] The effects of congenital brain serotonin deficiency on responses to chronic fluoxetine

BD Sachs, JPR Jacobsen, TL Thomas… - Translational …, 2013 - nature.com
The importance of reversing brain serotonin (5-HT) deficiency and promoting hippocampal
neurogenesis in the mechanisms of action for antidepressants remain highly controversial …