Inflammation reaction mediated by NLRP3 inflammasome and Nrf2-related oxidative stress
are vital participants in the development of diabetic nephropathy (DN) and closely …

Background: Diabetic nephropathy (DN) is one of the most serious complications of diabetes
mellitus and the main cause of the end-stage renal disease (ESRD). Activation of the NLRP3 …

Background Diabetic nephropathy (DN) is a lethal diabetic microvascular complication
characterized by chronic low-grade inflammation. The NOD-like receptor pyrin domain …

Diabetic nephropathy (DN) is a chronic diabetic microvascular complication. Hyperactivity of
the polyol pathway is involved in the pathogenesis of DN. Aldose reductase (AR), the rate …

Abstract Background The Nucleotide binding and oligomerization domain-like
receptorfamily pyrin domain-containing 3 (NLRP3)-inflammasome plays an important role in …

Diabetic kidney disease (DKD) is a prevalent and severe complications of diabetes and
serves as the primary cause of end-stage kidney disease (ESKD) globally. Increasing …

Activation of nucleotide-binding oligomerization domain-like receptor pyrin domain
containing 3 (NLRP3) inflammasome has been reported in diabetic complications including …

While a plethora of studies support a therapeutic benefit of Nrf2 activation and ROS
inhibition in diabetic nephropathy (dNP), the Nrf2 activator bardoxolone failed in clinical …

Background Nucleotide leukin-rich polypeptide 3 (NLRP3) inflammasome is documented as
a potent target for treating metabolic diseases and inflammatory disorders. Our recent work …

Abstract Background Toll-like receptors (TLRs) are critical sensors for the conservation of
bacterial molecules and play a key role in host defense against pathogens. The effect of …