Angiotensin II (AngII) is a pivotal peptide implicated in the regulation of blood pressure. In
addition to its systemic vascular and renal effects, AngII acts centrally to modulate the …

Angiotensin II–mediated vascular brain inflammation emerged as a novel
pathophysiological mechanism in neurogenic hypertension. However, the precise …

The renin–angiotensin–aldosterone system (RAAS) impacts cardiovascular homeostasis via
direct actions on peripheral blood vessels and via modulation of the autonomic nervous …

New Findings What is the topic of this review? This review highlights the importance of the
blood–brain barrier in the context of diseases involving autonomic dysfunction, such as …

Essential hypertension is a multifactorial disorder with a strong genetic predisposition.
Although anti-hypertensive medications have drastically reduced cardiovascular diseases …

Angiotensin II (AngII) is a key neuropeptide that acting within the brain hypothalamic
paraventricular nucleus regulates neurohumoral outflow to the circulation. Moreover, an …

Central infusion of Ang II (angiotensin II) has been associated with increased sympathetic
outflow resulting in neurogenic hypertension. In the present study, we appraised whether the …

Abstract Brain angiotensin II (Ang II) induces tonic sympathoexcitatory effects through AT 1
receptor stimulation of glutamatergic neurons and sympathoinhibitory effects via GABAergic …

The blood-brain barrier (BBB) is a complex multicellular structure acting as selective barrier
controlling the transport of substances between these compartments. Accumulating …

This review focuses on the dysfunction of the intrinsic brain renin–angiotensin system (RAS)
in the pathogenesis of hypertension. Hyperactivity of the brain RAS plays a critical role in …