Giving drugs a second chance: overcoming regulatory and financial hurdles in repurposing approved drugs as cancer therapeutics
JJ Hernandez, M Pryszlak, L Smith, C Yanchus… - Frontiers in …, 2017 - frontiersin.org
The repositioning or “repurposing” of existing therapies for alternative disease indications is
an attractive approach that can save significant investments of time and money during drug …
an attractive approach that can save significant investments of time and money during drug …
Drug repurposing in oncology—patient and health systems opportunities
In most countries, healthcare service budgets are not likely to support the current explosion
in the cost of new oncology drugs. Repurposing the large arsenal of approved, non …
in the cost of new oncology drugs. Repurposing the large arsenal of approved, non …
On-label or off-label? Overcoming regulatory and financial barriers to bring repurposed medicines to cancer patients
C Verbaanderd, I Rooman, L Meheus… - Frontiers in …, 2020 - frontiersin.org
Repurposing of medicines has gained a lot of interest from the research community in recent
years as it could offer safe, timely, and affordable new treatment options for cancer patients …
years as it could offer safe, timely, and affordable new treatment options for cancer patients …
Drug repurposing—an emerging strategy in cancer therapeutics
KS Turabi, A Deshmukh, S Paul, D Swami… - Naunyn-Schmiedeberg's …, 2022 - Springer
Cancer is a complex disease affecting millions of people around the world. Despite
advances in surgical and radiation therapy, chemotherapy continues to be an important …
advances in surgical and radiation therapy, chemotherapy continues to be an important …
Turning liabilities into opportunities: Off-target based drug repurposing in cancer
Targeted drugs and precision medicine have transformed the landscape of cancer therapy
and significantly improved patient outcomes in many cases. However, as therapies are …
and significantly improved patient outcomes in many cases. However, as therapies are …
Overcoming cancer therapeutic bottleneck by drug repurposing
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …
the development of the alternative strategy of drug repurposing, the development of old …
Repurposing drugs in oncology: next steps
C Verbaanderd, L Meheus, I Huys, P Pantziarka - Trends in cancer, 2017 - cell.com
The repurposing of existing non-cancer drugs is a potential source of new treatment options
for cancer patients with high unmet medical needs. While scientific research is progressing …
for cancer patients with high unmet medical needs. While scientific research is progressing …
Drug repurposing in cancer
L Sleire, HE Førde, IA Netland, L Leiss, BS Skeie… - Pharmacological …, 2017 - Elsevier
Cancer is a major health issue worldwide, and the global burden of cancer is expected to
increase in the coming years. Whereas the limited success with current therapies has driven …
increase in the coming years. Whereas the limited success with current therapies has driven …
Repurposing approved non-oncology drugs for cancer therapy: a comprehensive review of mechanisms, efficacy, and clinical prospects
Cancer poses a significant global health challenge, with predictions of increasing
prevalence in the coming years due to limited prevention, late diagnosis, and inadequate …
prevalence in the coming years due to limited prevention, late diagnosis, and inadequate …
Drug repurposing for cancer therapy, easier said than done
A Gonzalez-Fierro, A Dueñas-González - Seminars in cancer biology, 2021 - Elsevier
Drug repurposing for cancer therapy is currently a hot topic of research. Theoretically, in
contrast to the known hurdles of developing new molecular entities, the approach of …
contrast to the known hurdles of developing new molecular entities, the approach of …