Giving drugs a second chance: overcoming regulatory and financial hurdles in repurposing approved drugs as cancer therapeutics

JJ Hernandez, M Pryszlak, L Smith, C Yanchus… - Frontiers in …, 2017 - frontiersin.org
The repositioning or “repurposing” of existing therapies for alternative disease indications is
an attractive approach that can save significant investments of time and money during drug …

Drug repurposing in oncology—patient and health systems opportunities

F Bertolini, VP Sukhatme, G Bouche - Nature reviews Clinical oncology, 2015 - nature.com
In most countries, healthcare service budgets are not likely to support the current explosion
in the cost of new oncology drugs. Repurposing the large arsenal of approved, non …

On-label or off-label? Overcoming regulatory and financial barriers to bring repurposed medicines to cancer patients

C Verbaanderd, I Rooman, L Meheus… - Frontiers in …, 2020 - frontiersin.org
Repurposing of medicines has gained a lot of interest from the research community in recent
years as it could offer safe, timely, and affordable new treatment options for cancer patients …

Drug repurposing—an emerging strategy in cancer therapeutics

KS Turabi, A Deshmukh, S Paul, D Swami… - Naunyn-Schmiedeberg's …, 2022 - Springer
Cancer is a complex disease affecting millions of people around the world. Despite
advances in surgical and radiation therapy, chemotherapy continues to be an important …

Turning liabilities into opportunities: Off-target based drug repurposing in cancer

V Palve, Y Liao, LLR Rix, U Rix - Seminars in cancer biology, 2021 - Elsevier
Targeted drugs and precision medicine have transformed the landscape of cancer therapy
and significantly improved patient outcomes in many cases. However, as therapies are …

Overcoming cancer therapeutic bottleneck by drug repurposing

Z Zhang, L Zhou, N Xie, EC Nice, T Zhang… - Signal transduction and …, 2020 - nature.com
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …

Repurposing drugs in oncology: next steps

C Verbaanderd, L Meheus, I Huys, P Pantziarka - Trends in cancer, 2017 - cell.com
The repurposing of existing non-cancer drugs is a potential source of new treatment options
for cancer patients with high unmet medical needs. While scientific research is progressing …

Drug repurposing in cancer

L Sleire, HE Førde, IA Netland, L Leiss, BS Skeie… - Pharmacological …, 2017 - Elsevier
Cancer is a major health issue worldwide, and the global burden of cancer is expected to
increase in the coming years. Whereas the limited success with current therapies has driven …

Repurposing approved non-oncology drugs for cancer therapy: a comprehensive review of mechanisms, efficacy, and clinical prospects

R Mohi-Ud-Din, A Chawla, P Sharma, PA Mir… - European journal of …, 2023 - Springer
Cancer poses a significant global health challenge, with predictions of increasing
prevalence in the coming years due to limited prevention, late diagnosis, and inadequate …

Drug repurposing for cancer therapy, easier said than done

A Gonzalez-Fierro, A Dueñas-González - Seminars in cancer biology, 2021 - Elsevier
Drug repurposing for cancer therapy is currently a hot topic of research. Theoretically, in
contrast to the known hurdles of developing new molecular entities, the approach of …