Evolution to the rescue: using comparative genomics to understand long non-coding RNAs
I Ulitsky - Nature Reviews Genetics, 2016 - nature.com
Long non-coding RNAs (lncRNAs) have emerged in recent years as major players in a
multitude of pathways across species, but it remains challenging to understand which of …
multitude of pathways across species, but it remains challenging to understand which of …
Reverse-genetics studies of lncRNAs—what we have learnt and paths forward
F Gao, Y Cai, P Kapranov, D Xu - Genome biology, 2020 - Springer
Long non-coding RNAs (lncRNAs) represent a major fraction of the transcriptome in
multicellular organisms. Although a handful of well-studied lncRNAs are broadly recognized …
multicellular organisms. Although a handful of well-studied lncRNAs are broadly recognized …
Evolutionary analysis across mammals reveals distinct classes of long non-coding RNAs
Background Recent advances in transcriptome sequencing have enabled the discovery of
thousands of long non-coding RNAs (lncRNAs) across many species. Though several …
thousands of long non-coding RNAs (lncRNAs) across many species. Though several …
Genomic and functional conservation of lncRNAs: lessons from flies
Over the last decade, the increasing interest in long non-coding RNAs (lncRNAs) has led to
the discovery of these transcripts in multiple organisms. LncRNAs tend to be specifically …
the discovery of these transcripts in multiple organisms. LncRNAs tend to be specifically …
Evolutionary conservation of long non-coding RNAs; sequence, structure, function
P Johnsson, L Lipovich, D Grandér… - Biochimica et Biophysica …, 2014 - Elsevier
Background Recent advances in genomewide studies have revealed the abundance of long
non-coding RNAs (lncRNAs) in mammalian transcriptomes. The ENCODE Consortium has …
non-coding RNAs (lncRNAs) in mammalian transcriptomes. The ENCODE Consortium has …
lncRNAtor: a comprehensive resource for functional investigation of long non-coding RNAs
Motivation: A number of long non-coding RNAs (lncRNAs) have been identified by deep
sequencing methods, but their molecular and cellular functions are known only for a limited …
sequencing methods, but their molecular and cellular functions are known only for a limited …
Long noncoding RNAs: past, present, and future
JTY Kung, D Colognori, JT Lee - Genetics, 2013 - academic.oup.com
Long noncoding RNAs (lncRNAs) have gained widespread attention in recent years as a
potentially new and crucial layer of biological regulation. lncRNAs of all kinds have been …
potentially new and crucial layer of biological regulation. lncRNAs of all kinds have been …
Technologies to probe functions and mechanisms of long noncoding RNAs
Thousands of long noncoding RNAs (lncRNAs) have been discovered, but their functional
characterization has been slowed by a limited set of research tools. Here we review …
characterization has been slowed by a limited set of research tools. Here we review …
Unique features of long non-coding RNA biogenesis and function
Long non-coding RNAs (lncRNAs) are a diverse class of RNAs that engage in numerous
biological processes across every branch of life. Although initially discovered as mRNA-like …
biological processes across every branch of life. Although initially discovered as mRNA-like …
Discovery and annotation of long noncoding RNAs
JS Mattick, JL Rinn - Nature structural & molecular biology, 2015 - nature.com
Recent advances in RNA-sequencing technologies have led to the discovery of thousands
of previously unannotated noncoding transcripts, including many long noncoding RNAs …
of previously unannotated noncoding transcripts, including many long noncoding RNAs …