Biotherapies have revolutionized the treatment of RA. However, much work is needed to
understand all the mechanisms of these biotherapies, and alternatives are needed to …

Chapter summary Rheumatoid arthritis (RA) is the most common chronic autoimmunopathy,
clinically leading to joint destruction as a consequence of the chronic inflammatory …

T cells regulate the disease process in rheumatoid arthritis (RA) on multiple levels and
represent a logical choice for anti-inflammatory therapy. In the inflamed joint they promote …

Rheumatoid arthritis (RA), a systemic disease, is characterized by a chronic inflammatory
reaction in the synovium of joints and is associated with degeneration of cartilage and …

Rheumatoid arthritis (RA) is one of the most common autoimmune diseases and is
characterized by synovitis that causes joint damage. The introduction of biologic agents has …

Rheumatoid arthritis is the most common of a number of diseases in which inflammation and
tissue destruction is driven by an autoimmune process. Current therapy is inadequate, and …

With the advent of biological therapies, considerable advances have been achieved in the
treatment of inflammatory arthritis. These have arisen primarily from studies elucidating …

Objectives Most therapies for autoimmune and inflammatory diseases either neutralize or
suppress production of inflammatory cytokines produced by activated macrophages (eg …

Rheumatoid arthritis (RA) is a multifactorial disease characterized by chronic inflammation of
the joints. Both genetic and environmental factors are involved in the pathogenesis of joint …

Recently published studies confirm that the long-term use of biological agents targeting TNF-
α in therapy for rheumatoid arthritis (RA) gives rise to sustained improvement in symptoms …