Emerging concepts in autoimmune encephalomyelitis beyond the CD4/TH1 paradigm

H Batoulis, K Addicks, S Kuerten - Annals of Anatomy-Anatomischer …, 2010 - Elsevier
Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis
(EAE) have long been regarded as primarily T helper cell type 1-mediated diseases …

Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination

A Rostami, B Ciric - Journal of the neurological sciences, 2013 - Elsevier
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). The
etiology of MS is not well understood, but it is believed that myelin-specific CD4+ T cells play …

Current views on the roles of Th1 and Th17 cells in experimental autoimmune encephalomyelitis

M El-behi, A Rostami, B Ciric - Journal of Neuroimmune Pharmacology, 2010 - Springer
Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis
(EAE), are autoimmune demyelinating diseases of the central nervous system (CNS) …

Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis

HS Domingues, M Mues, H Lassmann, H Wekerle… - PloS one, 2010 - journals.plos.org
Background There is consensus that experimental autoimmune encephalomyelitis (EAE)
can be mediated by myelin specific T cells of Th1 as well as of Th17 phenotype, but the …

Th17 cells in central nervous system autoimmunity

C Sie, T Korn, M Mitsdoerffer - Experimental neurology, 2014 - Elsevier
Multiple sclerosis (MS) is the most important autoimmune disease of the central nervous
system (CNS). Its animal model experimental autoimmune encephalomyelitis (EAE) has …

[HTML][HTML] Cytokines and effector T cell subsets causing autoimmune CNS disease

F Petermann, T Korn - FEBS letters, 2011 - Elsevier
Although experimental autoimmune encephalomyelitis (EAE) is limited in its potency to
reproduce the entirety of clinical and histopathologic features of multiple sclerosis (MS), this …

Th1 not Th17 cells drive spontaneous MS-like disease despite a functional regulatory T cell response

DE Lowther, DL Chong, S Ascough, A Ettorre… - Acta …, 2013 - Springer
Multiple sclerosis is considered a disease of complex autoimmune etiology, yet there
remains a lack of consensus as to specific immune effector mechanisms. Recent analyses of …

Experimental autoimmune encephalomyelitis–achievements and prospective advances

H Batoulis, MS Recks, K Addicks, S Kuerten - Apmis, 2011 - Wiley Online Library
Batoulis H, Recks MS, Addicks K, Kuerten S. Experimental autoimmune encephalomyelitis–
achievements and prospective advances. APMIS 2011; 119: 819–30. Multiple sclerosis (MS) …

Cutting edge: Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis

RA O'Connor, CT Prendergast, CA Sabatos… - The Journal of …, 2008 - journals.aai.org
It has recently been proposed that experimental autoimmune encephalomyelitis, once
considered the classical Th1 disease, is predominantly Th17 driven. In this study we show …

T cells in multiple sclerosis and experimental autoimmune encephalomyelitis

JM Fletcher, SJ Lalor, CM Sweeney… - Clinical & …, 2010 - academic.oup.com
Multiple sclerosis (MS) is a demyelinating inflammatory disorder of the central nervous
system (CNS), which involves autoimmune responses to myelin antigens. Studies in …