Despite great strides being achieved in improving cancer patients' outcomes through better
therapies and combinatorial treatment, several hurdles still remain due to therapy …

Notwithstanding cancer patients benefit from a plethora of therapeutic alternatives, drug
resistance remains a critical hurdle. Indeed, the high mortality rate is associated with …

Nowadays, cancer has been a frequent disease, and the first or second most common cause
of death worldwide. Despite a better understanding of the biology of cancer cells, the …

Cancer is a multifactor and multistep process that is affected intrinsically by the genetic and
epigenetic makeup of tumor cells and extrinsically by the host microenvironment and …

Since last two decades, the major cancer research has focused on understanding the
characteristic properties and mechanism of formation of Cancer stem cells (CSCs), due to …

Cancer stem cells (CSCs) have been demonstrated in a variety of tumors and are thought to
act as a clonogenic core for the genesis of new tumor growth. This small subpopulation of …

Chemoresistance is a major problem in cancer therapy as cancer cells develop mechanisms
that counteract the effect of chemotherapeutic compounds, leading to relapse and the …

Metastasis is one of the most challenging issues in cancer patient management, and
effective therapies to specifically target disease progression are missing, emphasizing the …

A frequent observation in several malignancies is the development of resistance to therapy
that results in frequent tumor relapse and metastasis. Much of the tumor resistance …

Abstract Background Cancer stem cells (CSCs) are subpopulations of cancer cells sharing
similar characteristics as normal stem or progenitor cells such as self-renewal ability and …