Tumors are intricate ecosystems containing malignant components that generate adaptive
and evolutionarily driven abnormal tissues. Through self-renewal and differentiation …

Cancer handles an estimated 7.6 million deaths worldwide per annum. A recent theory
focuses on the role Cancer Stem Cells (CSCs) in driving tumorigenesis and disease …

Increasing studies have demonstrated that most tumors consisted a subpopulation of cells
with stem cell properties, known as cancer stem cells (CSCs). Accumulating evidence …

The niche is the environment in which stem cells reside and is responsible for the
maintenance of unique stem cell properties such as self‐renewal and an undifferentiated …

Modern tumor therapy has achieved considerable progress, but many tumors remain
refractory to treatment or relapse following initial remission. Recent evidence points to one …

Cancer stem cells (CSCs) comprise the subpopulation of tumor bulk and acquire resistant to
conventional therapies and are considered as the primary tumor initiator cells. Nowadays …

Resistance to chemotherapy and cancer relapse are major clinical challenges attributed to a
sub population of cancer stem cells (CSCs). The concept of CSCs has been the subject of …

Over a decade of research has confirmed the critical role of cancer stem-like cells (CSCs) in
tumor initiation, chemoresistance, and metastasis. Increasingly, CSC hierarchies have …

Traditional therapies against cancer, chemo-and radiotherapy, have multiple limitations that
lead to treatment failure and cancer recurrence. These limitations are related to systemic …

Tumors are composed of non-homogeneous cell populations exhibiting varying degrees of
genetic and functional heterogeneity. Cancer stem cells (CSCs) are capable of sustaining …