Tumors are composed of non-homogeneous cell populations exhibiting varying degrees of
genetic and functional heterogeneity. Cancer stem cells (CSCs) are capable of sustaining …

Most of the cancers are still incurable human diseases. According to recent findings,
especially targeting cancer stem cells (CSCs) is the most promising therapeutic strategy …

Clinical oncology is in need of therapeutic innovation. New hypotheses and concepts for
translation of basic research to novel diagnostics and therapeutics are called for. In this …

Cancer stem cells (CSCs) are a small subpopulation of cells within tumors with capabilities
of self-renewal, differentiation, and tumorigenicity when transplanted into an animal host. A …

Over the past few decades, substantial evidence has convincingly revealed the existence of
cancer stem cells (CSCs) as a minor subpopulation in cancers, contributing to an aberrantly …

Cancer progression to metastatic stages is still unmanageable and the promise of effective
anti-metastatic therapy remains largely unmet, emphasizing the need to develop novel …

Cells with “stemness” and tumor-initiating properties have been isolated from both
hematological and solid tumors. These cells denominated as cancer stem cells (CSCs) …

Simple Summary Cancer is one of the hardest pathologies to fight, being one of the main
causes of death worldwide despite the constant development of novel therapeutic strategies …

The term “cancer stem cells”(CSCs) refers to cancer cells that exhibit traits parallel to normal
stem cells, namely the potential to give rise to every type of cell identified in a tumor …

A wide range of studies suggest that most cancers are clonal and may represent the
progeny of a single cell, a cancer stem cell (CSC) endowed with the capacity to maintain …