Increasing studies have demonstrated a small proportion of cancer stem cells (CSCs) exist
in the cancer cell population. CSCs have powerful self-renewal capacity and tumor-initiating …

Cancer is one of the most serious diseases all over the world, and the cancer stem cell
(CSC) model accounts for tumor initiation, metastasis, drug resistance, and relapse. The …

Cancer stem cells (CSCs) represent a tumor subpopulation responsible for tumor metastasis
and resistance to chemo-and radiotherapy, ultimately leading to tumor relapse. As a …

Cancer is a widespread worldwide chronic disease. In most cases, the high mortality rate
from cancer correlates with a lack of clear symptoms, which results in late diagnosis for …

Current evidence indicates that a subpopulation of cancer cells, named cancer stem cells
(CSCs) or tumor-initiating cells, are responsible for the initiation, growth, metastasis, therapy …

Intratumoral heterogeneity is a major ongoing challenge in the effective therapeutic targeting
of cancer. Accumulating evidence suggests that a fraction of cells within a tumor termed …

Normal somatic stem cells (SC) are naturally resistant to chemotherapeutic agents due to
their expression of various membrane transporter molecules (such as MDR-1), detoxifying …

The study of cancer stem cells (CSCs) has shown that tumors are driven by a subpopulation
of self-renewing CSCs that retain the capacity to engender the various differentiated cell …

Recent advances in research on cancer have led to understand the pathogenesis of cancer
and development of new anticancer drugs. Despite of these advancements, many tumors …

Since their identification in 1994, cancer stem cells (CSCs) have been objects of intensive
study. Their properties and mechanisms of formation have become a major focus of current …