Health impact and toxicological effects of nanomaterials in the lung

M Kendall, S Holgate - Respirology, 2012 - Wiley Online Library
The manufacture, use and disposal of nanomaterials will result in increased human
exposures to engineered nanoparticles (ENPs), potentially via the lung. ENPs differ …

[HTML][HTML] The use of nanoparticles for targeted drug delivery in non-small cell lung cancer

JE Holder, C Ferguson, E Oliveira, C Lodeiro… - Frontiers in …, 2023 - frontiersin.org
Lung cancer is a global health problem affecting millions of people each year. Non-small
cell lung cancer (NSCLC) is the most common form of lung cancer with various conventional …

Delivery strategies for sustained drug release in the lungs

C Loira-Pastoriza, J Todoroff, R Vanbever - Advanced drug delivery reviews, 2014 - Elsevier
Drug delivery to the lungs by inhalation offers a targeted drug therapy for respiratory
diseases. However, the therapeutic efficacy of inhaled drugs is limited by their rapid …

Pulmonary drug delivery with aerosolizable nanoparticles in an ex vivo lung model

M Beck-Broichsitter, J Gauss, CB Packhaeuser… - International journal of …, 2009 - Elsevier
The use of colloidal carrier systems for pulmonary drug delivery is an emerging field of
interest in nanomedicine. The objective of this study was to compare the pulmonary …

[HTML][HTML] Pulmonary inhalation for disease treatment: Basic research and clinical translations

B Wang, L Wang, Q Yang, Y Zhang, T Qinglai, X Yang… - Materials Today Bio, 2024 - Elsevier
Pulmonary drug delivery has the advantages of being rapid, efficient, and well-targeted, with
few systemic side effects. In addition, it is non-invasive and has good patient compliance …

Physicochemical properties of nanoparticles affecting their fate and the physiological function of pulmonary surfactants

Q Liu, J Guan, R Song, X Zhang, S Mao - Acta biomaterialia, 2022 - Elsevier
Pulmonary drug delivery has drawn great attention due to its targeted local lung action,
reduced side effects, and ease of administration. However, inhaled nanoparticles (NPs) …

New perspectives in nanotherapeutics for chronic respiratory diseases

AL da Silva, FF Cruz, PRM Rocco, MM Morales - Biophysical reviews, 2017 - Springer
Abstract According to the World Health Organization (WHO), hundreds of millions of people
of all ages and in all countries suffer from chronic respiratory diseases, with particular …

Critical determinants of uptake and translocation of nanoparticles by the human pulmonary alveolar epithelium

AJ Thorley, P Ruenraroengsak, TE Potter, TD Tetley - Acs Nano, 2014 - ACS Publications
The ability to manipulate the size and surface properties of nanomaterials makes them a
promising vector for improving drug delivery and efficacy. Inhalation is a desirable route of …

Nanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases

M Smola, T Vandamme… - International journal of …, 2008 - Taylor & Francis
The purpose of this review is to discuss the impact of nanocarriers administered by
pulmonary route to treat and to diagnose respiratory and non respiratory diseases. Indeed …

Pulmonary targeting with biodegradable salbutamol-loaded nanoparticles

M Beck-Broichsitter, J Gauss, T Gessler… - Journal of aerosol …, 2010 - liebertpub.com
Background: Aerosol therapy using particulate drug carriers has become an increasingly
attractive method to deliver therapeutic or diagnostic compounds to the lung. Polymeric …