During acclimatization to the hypoxia of altitude, the cerebral circulation is exposed to
arterial hypoxia and hypocapnia, two stimuli with opposing influences on cerebral blood flow …

The effects of discontinuous hypoxia on cerebrovascular regulation in humans are unknown.
We hypothesized that five nocturnal hypoxic exposures (8 h/day) at a simulated altitude of …

The effects of partial acclimatization to high altitude (HA; 5,050 m) on cerebral metabolism
and cerebrovascular function have not been characterized. We hypothesized (1) increased …

Decreased arterial partial oxygen pressure (PaO2) below a certain level presents a strong
stimulus for increasing cerebral blood flow. Although several field studies examined the time …

We tested the hypothesis that, following exposure to high altitude, cerebrovascular reactivity
to CO2 and cerebral autoregulation would be attenuated. Such alterations may predispose …

Cerebral blood flow is known to increase in response to hypoxia and to decrease with
hypocapnia. It is not known, however, whether these responses are altered in high‐altitude …

We examined the cardiovascular and cerebrovascular responses to acute isocapnic (IH)
and poikilocapnic hypoxia (PH) in 10 men (25.7±4.2 yr, mean±SD). Heart rate (HR), mean …

We hypothesized that 1) acute severe hypoxia, but not hyperoxia, at sea level would impair
dynamic cerebral autoregulation (CA); 2) impairment in CA at high altitude (HA) would be …

Exposure to mild hypoxia elicits a characteristic cerebrovascular response in mammals,
including humans. Initially, cerebral blood flow (CBF) increases as much as twofold. The …

The fractional increase in cerebral blood flow (CBF) velocity (VCBF) from the control value
with 5-min steps of isocapnic hypoxia and hyperoxic hypercapnia was measured by …