The IL-6 gene maps to an area of chromosome 7 known to be significant for susceptibility to
inflammatory bowel disease. The functional effects of interleukin-6 (IL-6) polymorphisms in …

Although genetic predisposition for inflammatory bowel disease (IBD) is well established,
little is known about the accountable genes. The pathogenesis of IBD is characterized by an …

Interleukin‐10 (IL‐10) is an anti‐inflammatory cytokine. Its production in humans is under
genetic control, and genotype defines high or low producers of this cytokine. This study …

Abstract Interleukin-10 (IL-10) has a key role in regulating mucosal inflammation. The role of
functional polymorphisms at positions− 627 and− 1117 in the IL-10 gene as candidate …

Interleukin‐18 (IL‐18) is believed to be one of the most important cytokines in the
pathogenesis of inflammatory bowel disease (IBD). The aim of the study was to clarify the …

Abstract Interleukin-12 (IL-12) is a key cytokine for the induction of Th1 immune responses.
Recently, functional polymorphisms in IL-12p40 (IL12B) were found to be associated with …

Imbalances in the regulation of Th1 and Th2 lymphocytes are crucial in inflammatory bowel
diseases. Interleukin-4 is secreted by Th2 lymphocytes and downregulates cytokine …

Genetic linkage analysis in families with multiple cases of inflammatory bowel disease (IBD)
has mapped a gene which confers susceptibility to IBD to the pericentromeric region of …

Abstract Interleukin-4 (IL-4) is an important cytokine in mucosal immunity and plays a critical
role in the development of colitis inT-α cell receptor mutant mice. Functionally significant …

Recently, a T-to-C polymorphism at position− 295 in the promoter region of the human
interleukin-16 (IL-16) gene was reported. The expression of IL-16 is increased in …