Yersinia pestis (Yp)-one of the world's most deadly human pathogens-is the gram-negative
bacterium that causes pneumonic plague. Virulent antibiotic-resistant Yp strains exist and …

Inhalation of Yersinia pestis bacilli causes pneumonic plague, a rapidly progressing and
exceptionally virulent disease. Extensively antibiotic-resistant Y. pestis strains exist and we …

Vaccination with live attenuated Yersinia pestis confers protection against pneumonic
plague but is not considered safe for general use. Subunit plague vaccines containing the Y …

Pulmonary infection with the bacterium Yersinia pestis causes pneumonic plague, an often-
fatal disease for which no vaccine is presently available. Antibody-mediated humoral …

Septic bacterial pneumonias are a major cause of death worldwide. Several of the highest
priority bioterror concerns, including anthrax, tularemia, and plague, are caused by bacteria …

An important virulence strategy evolved by bacterial pathogens to overcome host defenses
is the modulation of host cell death. Previous observations have indicated that Yersinia …

Cell contact by the plague bacterium Yersinia pestis initiates the injection of several
virulence factors that target biochemical pathways critical for host clearance of bacteria …

Yersinia pestis (YP), the gram-negative plague bacterium, has shaped human history unlike
any other pathogen known to mankind. YP (transmitted by the bite of an infected flea) …

Current subunit vaccines provide partial protection against pneumonic plague if the infecting
Y. pestis strain is encapsulated (F1+). Here we describe YadC, a novel Y. pestis outer …

Three major plague pandemics caused by the gram-negative bacterium Yersinia pestis
have killed nearly 200 million people in human history. Due to its extreme virulence and the …