Generation of Yersinia pestis Attenuated Strains by Signature-Tagged Mutagenesis in Search of Novel Vaccine Candidates
Y Flashner, E Mamroud, A Tidhar, R Ber… - Infection and …, 2004 - Am Soc Microbiol
In a search for novel attenuated vaccine candidates for use against Yersinia pestis, the
causative agent of plague, a signature-tagged mutagenesis strategy was used and …
causative agent of plague, a signature-tagged mutagenesis strategy was used and …
Pulmonary infection by Yersinia pestis rapidly establishes a permissive environment for microbial proliferation
PA Price, J Jin, WE Goldman - Proceedings of the National …, 2012 - National Acad Sciences
Disease progression of primary pneumonic plague is biphasic, consisting of a
preinflammatory and a proinflammatory phase. During the long preinflammatory phase …
preinflammatory and a proinflammatory phase. During the long preinflammatory phase …
Dual-Function Antibodies to Yersinia pestis LcrV Required for Pulmonary Clearance of Plague
NA Eisele, DM Anderson - Clinical and Vaccine Immunology, 2009 - Am Soc Microbiol
Yersinia pestis causes pneumonic plague, a necrotic pneumonia that rapidly progresses to
death without early treatment. Antibodies to the protective antigen LcrV are thought to …
death without early treatment. Antibodies to the protective antigen LcrV are thought to …
Yersinia pestis CO92ΔyopH Is a Potent Live, Attenuated Plague Vaccine
SS Bubeck, PH Dube - Clinical and Vaccine Immunology, 2007 - Am Soc Microbiol
An in-frame deletion of the yopH gene in Yersinia pestis CO92 attenuates virulence in both
bubonic and pneumonic plague models. When it is used as a live, attenuated vaccine …
bubonic and pneumonic plague models. When it is used as a live, attenuated vaccine …
A DNA vaccine producing LcrV antigen in oligomers is effective in protecting mice from lethal mucosal challenge of plague
S Wang, D Heilman, F Liu, T Giehl, S Joshi, X Huang… - Vaccine, 2004 - Elsevier
There is an urgent need to develop effective vaccines against pneumonic plague, a highly
lethal and contagious disease caused by the Gram-negative bacterium Yersinia pestis. Here …
lethal and contagious disease caused by the Gram-negative bacterium Yersinia pestis. Here …
Yersinia pestis--etiologic agent of plague
RD Perry, JD Fetherston - Clinical microbiology reviews, 1997 - Am Soc Microbiol
Plague is a widespread zoonotic disease that is caused by Yersinia pestis and has had
devastating effects on the human population throughout history. Disappearance of the …
devastating effects on the human population throughout history. Disappearance of the …
Yersinia pestis biovar Microtus strain 201, an avirulent strain to humans, provides protection against bubonic plague in rhesus macaques
Yersinia pestis biovar Microtus is considered to be a virulent to larger mammals, including
guinea pigs, rabbits and humans. It may be used as live attenuated plague vaccine …
guinea pigs, rabbits and humans. It may be used as live attenuated plague vaccine …
Yersinia pestis survives in neutrophils and sends a PS to macrophages: bon appétit!
Editorial: Yersinia pestis survives in neutrophils and sends a PS to macrophages: bon
appétit! | Journal of Leukocyte Biology | Oxford Academic Skip to Main Content …
appétit! | Journal of Leukocyte Biology | Oxford Academic Skip to Main Content …
[HTML][HTML] Human Anti-Plague Monoclonal Antibodies Protect Mice from Yersinia pestis in a Bubonic Plague Model
X Xiao, Z Zhu, JL Dankmeyer, MM Wormald, RL Fast… - PloS one, 2010 - journals.plos.org
Yersinia pestis is the etiologic agent of plague that has killed more than 200 million people
throughout the recorded history of mankind. Antibiotics may provide little immediate relief to …
throughout the recorded history of mankind. Antibiotics may provide little immediate relief to …
Expression of a recombinant form of the V antigen of Yersinia pestis, using three different expression systems
S Carr, J Miller, SEC Leary, AM Bennett, A Ho… - Vaccine, 1999 - Elsevier
Yersinia pestis, the causative organism of plague, produces V antigen (LcrV), a bifunctional
protein with regulatory and virulence roles that has been shown to be highly protective …
protein with regulatory and virulence roles that has been shown to be highly protective …