In a search for novel attenuated vaccine candidates for use against Yersinia pestis, the
causative agent of plague, a signature-tagged mutagenesis strategy was used and …

Disease progression of primary pneumonic plague is biphasic, consisting of a
preinflammatory and a proinflammatory phase. During the long preinflammatory phase …

Yersinia pestis causes pneumonic plague, a necrotic pneumonia that rapidly progresses to
death without early treatment. Antibodies to the protective antigen LcrV are thought to …

An in-frame deletion of the yopH gene in Yersinia pestis CO92 attenuates virulence in both
bubonic and pneumonic plague models. When it is used as a live, attenuated vaccine …

There is an urgent need to develop effective vaccines against pneumonic plague, a highly
lethal and contagious disease caused by the Gram-negative bacterium Yersinia pestis. Here …

Plague is a widespread zoonotic disease that is caused by Yersinia pestis and has had
devastating effects on the human population throughout history. Disappearance of the …

Yersinia pestis biovar Microtus is considered to be a virulent to larger mammals, including
guinea pigs, rabbits and humans. It may be used as live attenuated plague vaccine …

Editorial: Yersinia pestis survives in neutrophils and sends a PS to macrophages: bon
appétit! | Journal of Leukocyte Biology | Oxford Academic Skip to Main Content …

Yersinia pestis is the etiologic agent of plague that has killed more than 200 million people
throughout the recorded history of mankind. Antibiotics may provide little immediate relief to …

Yersinia pestis, the causative organism of plague, produces V antigen (LcrV), a bifunctional
protein with regulatory and virulence roles that has been shown to be highly protective …