Three single-nucleotide polymorphisms in LPA account for most of the increase in lipoprotein (a) level elevation in African Americans compared with European …
JP Chretien, J Coresh, Y Berthier-Schaad… - Journal of medical …, 2006 - jmg.bmj.com
Background: The extent which universally common or population-specific alleles can
explain between-population variations in phenotypes is unknown. The heritable coronary …
explain between-population variations in phenotypes is unknown. The heritable coronary …
[HTML][HTML] Genome-and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study
Abstract Lipoprotein (a)(Lp (a)) is an independent risk factor for cardiovascular disease. Lp
(a) levels in African Americans (AAs) are much higher compared with that in European …
(a) levels in African Americans (AAs) are much higher compared with that in European …
[HTML][HTML] Variation in LPA Is Associated with Lp(a) Levels in Three Populations from the Third National Health and Nutrition Examination Survey
L Dumitrescu, K Glenn, K Brown-Gentry, C Shephard… - PLoS …, 2011 - journals.plos.org
The distribution of lipoprotein (a)[Lp (a)] levels can differ dramatically across diverse
racial/ethnic populations. The extent to which genetic variation in LPA can explain these …
racial/ethnic populations. The extent to which genetic variation in LPA can explain these …
Comprehensive Analysis of Genomic Variation in the LPA Locus and Its Relationship to Plasma Lipoprotein(a) in South Asians, Chinese, and European Caucasians
Background—Functional copy number variation in the apolipoprotein (a) gene (LPA)
underlies a variable number of protein kringle domains repeated in tandem in the lipoprotein …
underlies a variable number of protein kringle domains repeated in tandem in the lipoprotein …
[HTML][HTML] Single-Nucleotide Polymorphisms in LPA Explain Most of the Ancestry-Specific Variation in Lp(a) Levels in African Americans
Lipoprotein (a)(Lp (a)) is an important causal cardiovascular risk factor, with serum Lp (a)
levels predicting atherosclerotic heart disease and genetic determinants of Lp (a) levels …
levels predicting atherosclerotic heart disease and genetic determinants of Lp (a) levels …
Genetic control of lipoprotein (a) concentrations is different in Africans and Caucasians
M Scholz, HG Kraft, A Lingenhel, R Delport… - European Journal of …, 1999 - nature.com
Abstract Lipoprotein (a)(Lp (a)) represents a quantitative trait in human plasma associated
with atherothrombotic disease. Large variation in the distribution of Lp (a) concentrations …
with atherothrombotic disease. Large variation in the distribution of Lp (a) concentrations …
Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels
W Lu, YC Cheng, K Chen, H Wang… - Human molecular …, 2015 - academic.oup.com
Abstract Lipoprotein (a)[Lp (a)] is an independent risk factor for atherosclerosis-related
events that is under strong genetic control (heritability= 0.68–0.98). However, causal …
events that is under strong genetic control (heritability= 0.68–0.98). However, causal …
Serum distribution of lipoprotein (a) in African Americans and Nigerians: Potential evidence for a genotype‐environmental effect
CN Rotimi, RS Cooper, SM Marcovina… - Genetic …, 1997 - Wiley Online Library
Differences in lipoprotein (a)[Lp (a)] levels across populations have been described and
blacks are known to have higher Lp (a) values compared to whites. However, environmental …
blacks are known to have higher Lp (a) values compared to whites. However, environmental …
A Common LPA Null Allele Associates With Lower Lipoprotein(a) Levels and Coronary Artery Disease Risk
T Kyriakou, U Seedorf, A Goel… - … , and vascular biology, 2014 - Am Heart Assoc
Objective—Increased levels of lipoprotein (a) are a highly heritable risk factor for coronary
artery disease (CAD). The genetic determinants of lipoprotein (a) levels are mainly because …
artery disease (CAD). The genetic determinants of lipoprotein (a) levels are mainly because …
Genome-Wide Association Study and Identification of a Protective Missense Variant on Lipoprotein (a) Concentration: Protective Missense Variant on Lipoprotein (a) …
MA Said, MW Yeung, YJ van de Vegte… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Lipoprotein (a)(Lp [a]) is associated with coronary artery disease (CAD) but also
to LDL (low-density lipoprotein) cholesterol. The genetic architecture of Lp (a) remains …
to LDL (low-density lipoprotein) cholesterol. The genetic architecture of Lp (a) remains …