Three single-nucleotide polymorphisms in LPA account for most of the increase in lipoprotein (a) level elevation in African Americans compared with European …

JP Chretien, J Coresh, Y Berthier-Schaad… - Journal of medical …, 2006 - jmg.bmj.com
Background: The extent which universally common or population-specific alleles can
explain between-population variations in phenotypes is unknown. The heritable coronary …

[HTML][HTML] Genome-and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study

J Li, LA Lange, J Sabourin, Q Duan, W Valdar… - Journal of human …, 2015 - nature.com
Abstract Lipoprotein (a)(Lp (a)) is an independent risk factor for cardiovascular disease. Lp
(a) levels in African Americans (AAs) are much higher compared with that in European …

[HTML][HTML] Variation in LPA Is Associated with Lp(a) Levels in Three Populations from the Third National Health and Nutrition Examination Survey

L Dumitrescu, K Glenn, K Brown-Gentry, C Shephard… - PLoS …, 2011 - journals.plos.org
The distribution of lipoprotein (a)[Lp (a)] levels can differ dramatically across diverse
racial/ethnic populations. The extent to which genetic variation in LPA can explain these …

Comprehensive Analysis of Genomic Variation in the LPA Locus and Its Relationship to Plasma Lipoprotein(a) in South Asians, Chinese, and European Caucasians

MB Lanktree, SS Anand, S Yusuf… - Circulation …, 2010 - Am Heart Assoc
Background—Functional copy number variation in the apolipoprotein (a) gene (LPA)
underlies a variable number of protein kringle domains repeated in tandem in the lipoprotein …

[HTML][HTML] Single-Nucleotide Polymorphisms in LPA Explain Most of the Ancestry-Specific Variation in Lp(a) Levels in African Americans

RC Deo, JG Wilson, C Xing, K Lawson, WHL Kao… - PloS one, 2011 - journals.plos.org
Lipoprotein (a)(Lp (a)) is an important causal cardiovascular risk factor, with serum Lp (a)
levels predicting atherosclerotic heart disease and genetic determinants of Lp (a) levels …

Genetic control of lipoprotein (a) concentrations is different in Africans and Caucasians

M Scholz, HG Kraft, A Lingenhel, R Delport… - European Journal of …, 1999 - nature.com
Abstract Lipoprotein (a)(Lp (a)) represents a quantitative trait in human plasma associated
with atherothrombotic disease. Large variation in the distribution of Lp (a) concentrations …

Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels

W Lu, YC Cheng, K Chen, H Wang… - Human molecular …, 2015 - academic.oup.com
Abstract Lipoprotein (a)[Lp (a)] is an independent risk factor for atherosclerosis-related
events that is under strong genetic control (heritability= 0.68–0.98). However, causal …

Serum distribution of lipoprotein (a) in African Americans and Nigerians: Potential evidence for a genotype‐environmental effect

CN Rotimi, RS Cooper, SM Marcovina… - Genetic …, 1997 - Wiley Online Library
Differences in lipoprotein (a)[Lp (a)] levels across populations have been described and
blacks are known to have higher Lp (a) values compared to whites. However, environmental …

A Common LPA Null Allele Associates With Lower Lipoprotein(a) Levels and Coronary Artery Disease Risk

T Kyriakou, U Seedorf, A Goel… - … , and vascular biology, 2014 - Am Heart Assoc
Objective—Increased levels of lipoprotein (a) are a highly heritable risk factor for coronary
artery disease (CAD). The genetic determinants of lipoprotein (a) levels are mainly because …

Genome-Wide Association Study and Identification of a Protective Missense Variant on Lipoprotein (a) Concentration: Protective Missense Variant on Lipoprotein (a) …

MA Said, MW Yeung, YJ van de Vegte… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Lipoprotein (a)(Lp [a]) is associated with coronary artery disease (CAD) but also
to LDL (low-density lipoprotein) cholesterol. The genetic architecture of Lp (a) remains …