Lipoprotein (a) as a potential causal genetic risk factor of cardiovascular disease: a rationale for increased efforts to understand its pathophysiology and develop …
S Tsimikas, JL Hall - Journal of the American College of Cardiology, 2012 - jacc.org
Recent published studies have provided increasing evidence that lipoprotein (a)[Lp (a)] may
be a potential causal, genetic, independent risk factor for cardiovascular disease (CVD). Lp …
be a potential causal, genetic, independent risk factor for cardiovascular disease (CVD). Lp …
The LPA gene C93T polymorphism influences plasma lipoprotein (a) levels and is independently associated with susceptibility to peripheral arterial disease
M Catalano, A Cortelazzo, Y Yilmaz, E Perilli… - Clinica Chimica …, 2008 - Elsevier
BACKGROUND: Plasma lipoprotein (a)[Lp (a)] levels are mainly genetically determined. The
C93T polymorphism is a naturally occurring variant of the LPA gene that may influence Lp …
C93T polymorphism is a naturally occurring variant of the LPA gene that may influence Lp …
[HTML][HTML] Heritability of apolipoprotein (a) traits in two-generational African-American and Caucasian families [S]
B Enkhmaa, E Anuurad, W Zhang, K Kim… - Journal of lipid …, 2019 - ASBMB
Heritability of LPA allele, apo (a) isoform sizes, and isoform-associated lipoprotein (a)[Lp (a)]
levels was studied in 82 Caucasian and African-American families with two parents and two …
levels was studied in 82 Caucasian and African-American families with two parents and two …
[HTML][HTML] Human genetics and the causal role of lipoprotein (a) for various diseases
F Kronenberg - Cardiovascular drugs and therapy, 2016 - Springer
Abstract Lipoprotein (a)[Lp (a)] is a highly atherogenic lipoprotein that is under strong
genetic control by the LPA gene locus. Genetic variants including a highly polymorphic copy …
genetic control by the LPA gene locus. Genetic variants including a highly polymorphic copy …
Associations of genetically predicted Lp (a)(lipoprotein [a]) levels with cardiovascular traits in individuals of European and African Ancestry
Background: Lp (a)(lipoprotein [a]) levels are higher in individuals of African ancestry (AA)
than in individuals of European ancestry (EA). We examined associations of genetically …
than in individuals of European ancestry (EA). We examined associations of genetically …
Significant impact of the+ 93 C/T polymorphism in the apolipoprotein (a) gene on Lp (a) concentrations in Africans but not in Caucasians: confounding effect of linkage …
HG Kraft, M Windegger, HJ Menzel… - Human molecular …, 1998 - academic.oup.com
Abstract Lipoprotein (a)[Lp (a)] is a quantitative genetic trait in human plasma associated
with atherothrombotic disease. The major determinant of Lp (a) concentration is the …
with atherothrombotic disease. The major determinant of Lp (a) concentration is the …
[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene
S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
Abstract High lipoprotein (a)[Lp (a)] concentrations are one of the most important genetically
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …
Predictors of lipoprotein (a) levels in a European and South Asian population in the Newcastle Heart Project
A Tavridou, N Unwin, R Bhopal… - European journal of …, 2003 - Wiley Online Library
Background Understanding of the higher susceptibility of South Asians to coronary heart
disease is limited. One explanation is the combination of high prevalence of insulin …
disease is limited. One explanation is the combination of high prevalence of insulin …
Characterization of the genetic elements controlling lipoprotein (a) concentrations in Mexican Americans. Evidence for at least three controlling elements linked to LPA …
DL Rainwater, CM Kammerer, JL VandeBerg… - Atherosclerosis, 1997 - Elsevier
Analyses of 1163 samples from the San Antonio Family Heart Study revealed several
elements of genetic control of lipoprotein (a)(Lp (a)) concentrations in Mexican Americans …
elements of genetic control of lipoprotein (a)(Lp (a)) concentrations in Mexican Americans …
Genetics of plasma lipoprotein (a) concentrations
E Boerwinkle - Current Opinion in Lipidology, 1992 - journals.lww.com
Abstract Lipoprotein (a)[Lp (a)] is a low-density-like lipoprotein with the addition of a Lp (a)-
specific protein, apolipoprotein (a)[apo (a)]. Plasma concentrations of Lp (a) are a risk factor …
specific protein, apolipoprotein (a)[apo (a)]. Plasma concentrations of Lp (a) are a risk factor …