Synthesis, anticancer activity, SAR and binding mode of interaction studies of substituted pentanoic acids: part II
Aim: Our previous results suggest that phenyl/naphthylacetyl pentanoic acid derivatives may
exhibit dual MMP-2 and HDAC8 inhibitory activities and show effective cytotoxic properties …
exhibit dual MMP-2 and HDAC8 inhibitory activities and show effective cytotoxic properties …
Synthesis, anticancer activity, structure–activity relationship and binding mode of interaction studies of substituted pentanoic acids
Aim: Simultaneous inhibition of MMP-2 and HDAC8 may be an effective strategy to target
cancer. Methodology: In continuation of our earlier efforts, a series of substituted pentanoic …
cancer. Methodology: In continuation of our earlier efforts, a series of substituted pentanoic …
A pentanoic acid derivative targeting matrix metalloproteinase-2 (MMP-2) induces apoptosis in a chronic myeloid leukemia cell line
A Mukherjee, N Adhikari, T Jha - European Journal of Medicinal Chemistry, 2017 - Elsevier
Depending on our previous observations, some compounds of pentanoic acid were
designed and synthesized. Characterization of the synthesized compounds was done by …
designed and synthesized. Characterization of the synthesized compounds was done by …
Exploring novel capping framework: High substituent pyridine-hydroxamic acid derivatives as potential antiproliferative agents
F Hernández-Borja, I Mercado-Sánchez… - DARU Journal of …, 2021 - Springer
Abstract Purpose Histone deacetylases (HDACs) play a vital role in the epigenetic
regulation of gene expression due to their overexpression in several cancer forms …
regulation of gene expression due to their overexpression in several cancer forms …
Novel β‑hydroxy ketones: Synthesis, spectroscopic characterization, molecular docking, and anticancer activity studies
In this study, a series of novel β‑hydroxy ketone derivatives 3a-o were designed,
synthesized, and evaluated for their anticancer activity. The structure of these compounds …
synthesized, and evaluated for their anticancer activity. The structure of these compounds …
Quantitative structure–cytotoxicity relationship of phenylpropanoid amides
C Shimada, Y Uesawa, M Ishihara, H Kagaya… - Anticancer …, 2014 - ar.iiarjournals.org
Background: A total of 12 phenylpropanoid amides were subjected to quantitative structure–
activity relationship (QSAR) analysis, based on their cytotoxicity, tumor selectivity and anti …
activity relationship (QSAR) analysis, based on their cytotoxicity, tumor selectivity and anti …
3D-QSAR studies on Maslinic acid analogs for Anticancer activity against Breast Cancer cell line MCF-7
Global prevalence of breast cancer and its rising frequency makes it a key area of research
in drug discovery programs. The research article describes the development of field based …
in drug discovery programs. The research article describes the development of field based …
Structure-based design, structure–activity relationship analysis, and antitumor activity of diaryl ether derivatives
SM Yang, ZN Huang, ZS Zhou, J Hou… - Archives of pharmacal …, 2015 - Springer
To identify novel therapeutic agents to treat cancer, we synthesized a series of diaryl ether
derivatives. Structure–activity relationship studies revealed that the presence of a chlorine or …
derivatives. Structure–activity relationship studies revealed that the presence of a chlorine or …
[HTML][HTML] Triazene salts: Design, synthesis, ctDNA interaction, lipophilicity determination, DFT calculation, and antiproliferative activity against human cancer cell lines
J Cytarska, A Anisiewicz… - Saudi Pharmaceutical …, 2019 - Elsevier
Synthesis, characterization and investigation of antiproliferative activity of nine triazene salts
against human cancer cells lines (MV-4-11, MCF-7, JURKAT, HT-29, Hep-G2, HeLa, Du-145 …
against human cancer cells lines (MV-4-11, MCF-7, JURKAT, HT-29, Hep-G2, HeLa, Du-145 …
Synthesis and anticancer activity of novel derivatives of α, β‐unsaturated ketones based on oleanolic acid: in vitro and in silico studies against prostate cancer cells
Herein, new derivatives of α, β-unsaturated ketones based on oleanolic acid (4 ai) were
designed, synthesized, characterized, and tested against human prostate cancer (PC3) …
designed, synthesized, characterized, and tested against human prostate cancer (PC3) …