Honokiol has previously been shown to be an effective anxiolytic-like agent in mice when
administered for 7 days at 0.2 mg/kg/day prior to evaluation in an elevated plus-maze, while …

Previous studies in this laboratory revealed that dihydrohonokiol‐B (DHH‐B; 3′‐(2
propenyl)‐5‐propyl‐(1, 1′‐biphenyl)‐2, 4′‐diol), a partially reduced derivative of …

This paper provides an overview of the pharmacological features of honokiol (3′, 5‐di‐2‐
propenyl‐1, 1′‐biphenyl‐2, 4′‐diol), an isomer of neolignans isolated and identified from …

Honokiol, a neolignane derivative of Magnolia bark, has central depressant action and, at
much lower doses, anxiolytic activity. We have investigated the characteristics of the …

An improved elevated plus-maze test in mice revealed that seven daily treatments with two
differnt traditional Chinese medicines, known as Kampo medicines in Japan, Hange-koboku …

The National Center for Complementary and Alternative Medicine (NCCAM) estimates that
nearly 40% of adults in the United States use alternative medicines, often in the form of an …

Honokiol and magnolol have been identified as modulators of the GABAA receptors in vitro.
Our previous study suggested a possible selectivity of honokiol and magnolol on GABAA …

In our previous study using an improved elevated plus‐maze in mice, the oriental herbal
medicine Saiboku‐to prolonged the time spent in open arms, showing an anxiolytic effect …

Use of the elevated plus-maze experiment and activity and traction tests in mice have
revealed that seven daily treatments with 0.2 mg kg (-1) and higher doses of honokiol, a …

Honokiol, an active agent extracted from magnolia bark, has been reported that induces
anxiolytic action in a mouse elevated plus-maze test. However, the mechanism of anxiolytic …