Orally administration of cerium oxide nanozyme for computed tomography imaging and anti-inflammatory/anti-fibrotic therapy of inflammatory bowel disease

Y Cao, K Cheng, M Yang, Z Deng, Y Ma, X Yan… - Journal of …, 2023 - Springer
Background Inflammatory bowel disease (IBD) is a chronic nonspecific disease with
unknown etiology. Currently, the anti-inflammatory therapeutic approaches have achieved a …

A drug-free nanozyme for mitigating oxidative stress and inflammatory bowel disease

F Zeng, Y Shi, C Wu, J Liang, Q Zhong, K Briley… - Journal of …, 2022 - Springer
Inflammatory bowel disease (IBD) is an incurable disease of the gastrointestinal tract with a
lack of effective therapeutic strategies. The proinflammatory microenvironment plays a …

Hyaluronic acid/serotonin-decorated cerium dioxide nanomedicine for targeted treatment of ulcerative colitis

Y Gao, J Zou, B Chen, Y Cao, D Hu, Y Zhang… - Biomaterials …, 2023 - pubs.rsc.org
Ulcerative colitis (UC) is a chronic nonspecific inflammatory bowel disease often
characterized by rapid progression and frequent comorbidities that make its treatment …

Metal polyphenol network/cerium oxide artificial enzymes therapeutic nanoplatform for MRI/CT-aided intestinal inflammation management

Z Deng, W Ma, C Ding, C Wei, B Gao, Y Zhu, Y Zhang… - Nano Today, 2023 - Elsevier
Intestinal inflammation, such as ulcerative colitis (UC), is a condition in which there is
chronic or recurring inflammation of the gastrointestinal tract. Designing safe, effective, and …

An Orally Administered CeO2@Montmorillonite Nanozyme Targets Inflammation for Inflammatory Bowel Disease Therapy

S Zhao, Y Li, Q Liu, S Li, Y Cheng… - Advanced Functional …, 2020 - Wiley Online Library
Safe, effective, and convenient administration of therapeutic nanomaterials is one of the
greatest difficulties in nanomedicine. To tackle this challenge, a system which couples multi …

Multifunctional nanozyme hydrogel with mucosal healing activity for single-dose ulcerative colitis therapy

C Cheng, Y Cheng, S Zhao, Q Wang, S Li… - Bioconjugate …, 2021 - ACS Publications
Nanozymes are nanomaterials with enzyme-like activities, which have been developed for
inflammatory disease therapy by reactive oxygen species (ROS) scavenging. The …

Polydopamine modified ceria nanorods alleviate inflammation in colitis by scavenging ROS and regulating macrophage M2 polarization

B Zhang, Q Li, Q Xu, B Li, H Dong… - International Journal of …, 2023 - Taylor & Francis
Background Inflammatory bowel disease (IBD) is closely related to higher intracellular
oxidative stress. Therefore, developing a novel method to scavenge the harmful reactive …

Biomimetic MOF nanoparticles delivery of C-dot nanozyme and CRISPR/Cas9 system for site-specific treatment of ulcerative colitis

Y Ma, W Gao, Y Zhang, M Yang, X Yan… - … Applied Materials & …, 2022 - ACS Publications
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) of unknown etiology
affecting the colon and rectum. Previous studies have found that reactive oxygen species …

Construction of pH‐Dependent Nanozymes with Oxygen Vacancies as the High‐Efficient Reactive Oxygen Species Scavenger for Oral‐Administrated Anti …

N Zhao, FE Yang, CY Zhao, SW Lv… - Advanced …, 2021 - Wiley Online Library
It is of great significance to eliminate excessive reactive oxygen species (ROS) for treating
inflammatory bowel disease (IBD). Herein, for the first time, a novel nanozyme NiCo2O4 …

Dextran-coated cerium oxide nanoparticles: a computed tomography contrast agent for imaging the gastrointestinal tract and inflammatory bowel disease

PC Naha, JC Hsu, J Kim, S Shah, M Bouché… - ACS …, 2020 - ACS Publications
Computed tomography (CT) is an X-ray-based medical imaging technique commonly used
for noninvasive gastrointestinal tract (GIT) imaging. Iodine-and barium-based CT contrast …