Adaptive immunity is initiated in secondary lymphoid tissues when naive T cells recognize
foreign antigen presented as MHC-bound peptide on the surface of dendritic cells. Only a …

Dendritic cells (DCs) capture pathogens and foreign antigen (Ag) in peripheral tissues and
migrate to secondary lymphoid tissues, such as lymph nodes (LNs), where they present …

The immune system is a dynamic and multi-level biological system that protects host
organisms against invading pathogens and tumor development, and plays an active role in …

Generating adaptive immunity after infection or immunization requires physical interactions
within a lymph node (LN) T-zone between antigen-bearing dendritic cells (DCs) that arrive …

The lymph node is a highly structured organ that mediates the body's adaptive immune
response to antigens and other foreign particles. Central to its function is the distinct spatial …

Immune responses occur as a result of stochastic interactions between a plethora of different
cell types and molecules that regulate the migration and function of innate and adaptive …

The cells of the immune system respond to a great variety of different signals that frequently
reach them simultaneously. Computational models of signaling pathways and cellular …

We develop a mathematical framework for modeling regulatory mechanisms in the immune
system. The model describes dynamics of key components of the immune network within …

Recent intravital microscopy experiments have revealed the complex behavior of T cells
within lymph nodes. Modeling T‐cell responses in lymph nodes now requires integration of …

Adaptive immune responses develop in secondary lymphoid organs such as lymph nodes
(LNs) in a well-coordinated series of interactions between migrating immune cells and …