The macronutrients glucose, lipids, and amino acids are the major components that maintain
life. The ability of cells to sense and respond to fluctuations in these nutrients is a crucial …

Elucidating the cellular and molecular basis of nutrient metabolism and regulation of feeding
has become a major focus in scientific research over the last twenty years. Because of the …

The proper functioning of the pathways that are involved in the sensing and management of
nutrients is central to metabolic homeostasis and is therefore among the most fundamental …

In eukaryotic cells, G-protein-coupled receptors (GPCRs), non-transporting nutrient carrier
homologues and active nutrient carriers have been recently shown to function as sensors …

The interaction between selective nutrients and linked genes involving a specific organ
reveals the genetic make-up of an individual in response to a particular nutrient. The …

In type 2 diabetes and obesity, the homeostatic control of glucose and energy balance is
impaired, leading to hyperglycemia and hyperphagia. Recent studies indicate that nutrient …

The gastrointestinal tract maintains energy and glucose homeostasis, in part through
nutrient-sensing and subsequent signaling to the brain and other tissues. In this review, we …

The ability to sense and respond to fluctuations in environmental nutrient levels is a requisite
for life. Nutrient scarcity is a selective pressure that has shaped the evolution of most cellular …

There is an intimate, yet poorly understood, link between cellular metabolic status, cell
signalling and transcription. Central metabolic pathways are under the control of signalling …

Sensing and responding to changes in nutrient levels, including those of glucose, lipids, and
amino acids, by the body is necessary for survival. Accordingly, perturbations in nutrient …