Downregulation of myostatin pathway in neuromuscular diseases may explain challenges of anti-myostatin therapeutic approaches
Muscular dystrophies are characterized by weakness and wasting of skeletal muscle
tissues. Several drugs targeting the myostatin pathway have been used in clinical trials to …
tissues. Several drugs targeting the myostatin pathway have been used in clinical trials to …
Targeting myostatin for therapies against muscle-wasting disorders.
K Tsuchida - Current Opinion in Drug Discovery & Development, 2008 - europepmc.org
In addition to gene correction therapy and cell transplantation techniques, multidisciplinary
approaches to drug discovery and development offer promising therapeutic strategies for …
approaches to drug discovery and development offer promising therapeutic strategies for …
Antimyostatin treatment in health and disease: The story of great expectations and limited success
TL Nielsen, J Vissing, TO Krag - Cells, 2021 - mdpi.com
In the past 20 years, myostatin, a negative regulator of muscle mass, has attracted attention
as a potential therapeutic target in muscular dystrophies and other conditions. Preclinical …
as a potential therapeutic target in muscular dystrophies and other conditions. Preclinical …
The function of Myostatin and strategies of Myostatin blockade—new hope for therapies aimed at promoting growth of skeletal muscle
K Patel, H Amthor - Neuromuscular Disorders, 2005 - Elsevier
Genetic deletion of Myostatin, a member of the Transforming Growth Factor-beta family of
signalling molecules, resulted in excessive growth of skeletal muscle. It demonstrated the …
signalling molecules, resulted in excessive growth of skeletal muscle. It demonstrated the …
Myostatin in the pathophysiology of skeletal muscle
A Bonnieu, G Carnac, B Vernus - Current genomics, 2007 - ingentaconnect.com
Myostatin is an endogenous, negative regulator of muscle growth determining both muscle
fiber number and size. The myostatin pathway is conserved across diverse species ranging …
fiber number and size. The myostatin pathway is conserved across diverse species ranging …
[PDF][PDF] Myostatin: biology and clinical relevance
G Carnac, S Ricaud, B Vernus… - Mini reviews in medicinal …, 2006 - researchgate.net
Myostatin is a negative regulator of muscle mass. Important advances in our understanding
of the complex biology of this factor have revealed the therapeutic potential of antagonizing …
of the complex biology of this factor have revealed the therapeutic potential of antagonizing …
Systemic myostatin inhibition via liver-targeted gene transfer in normal and dystrophic mice
KJ Morine, LT Bish, K Pendrak, MM Sleeper… - PloS one, 2010 - journals.plos.org
Background Myostatin inhibition is a promising therapeutic strategy to maintain muscle mass
in a variety of disorders, including the muscular dystrophies, cachexia, and sarcopenia …
in a variety of disorders, including the muscular dystrophies, cachexia, and sarcopenia …
Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors
AM Haidet, L Rizo, C Handy… - Proceedings of the …, 2008 - National Acad Sciences
Increasing the size and strength of muscles represents a promising therapeutic strategy for
musculoskeletal disorders, and interest has focused on myostatin, a negative regulator of …
musculoskeletal disorders, and interest has focused on myostatin, a negative regulator of …
Molecular, cellular and physiological investigation of myostatin propeptide-mediated muscle growth in adult mice
A Matsakas, K Foster, A Otto, R Macharia… - Neuromuscular …, 2009 - Elsevier
Inhibition of myostatin signalling or its biological activity has recently emerged as a potential
remedial approach against muscle wasting and degenerative diseases such as muscular …
remedial approach against muscle wasting and degenerative diseases such as muscular …
Myostatin, a negative regulator of muscle mass: implications for muscle degenerative diseases
JF Tobin, AJ Celeste - Current opinion in pharmacology, 2005 - Elsevier
Myostatin is a secreted protein that negatively regulates skeletal muscle mass determining
both muscle fiber number and size. The myostatin pathway is conserved and regulates …
both muscle fiber number and size. The myostatin pathway is conserved and regulates …