Sepsis-induced immunosuppression

LK Torres, P Pickkers… - Annual review of …, 2022 - annualreviews.org
Sepsis is expected to have a substantial impact on public health and cost as its prevalence
increases. Factors contributing to increased prevalence include a progressively aging …

Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy

RS Hotchkiss, G Monneret, D Payen - Nature Reviews Immunology, 2013 - nature.com
Sepsis—which is a severe life-threatening infection with organ dysfunction—initiates a
complex interplay of host pro-inflammatory and anti-inflammatory processes. Sepsis can be …

Sepsis-induced immune dysfunction: can immune therapies reduce mortality?

MJ Delano, PA Ward - The Journal of clinical investigation, 2016 - Am Soc Clin Investig
Sepsis is a systemic inflammatory response induced by an infection, leading to organ
dysfunction and mortality. Historically, sepsis-induced organ dysfunction and lethality were …

Sepsis-induced immunosuppression: from bad to worse

RC Reddy, GH Chen, PK Tekchandani… - Immunologic …, 2001 - Springer
The sepsis syndrome is characterized by the acute release of a variety of inflammatory
mediators, which often result in detrimental effects to the host. The release of these …

[PDF][PDF] The immunology of sepsis

T van der Poll, M Shankar-Hari, WJ Wiersinga - Immunity, 2021 - cell.com
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection. This recently implemented definition does not capture the …

Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options

D Liu, SY Huang, JH Sun, HC Zhang, QL Cai… - Military Medical …, 2022 - Springer
Sepsis is a common complication of combat injuries and trauma, and is defined as a life-
threatening organ dysfunction caused by a dysregulated host response to infection. It is also …

[HTML][HTML] Advances in immune monitoring approaches for sepsis-induced immunosuppression

RQ Yao, C Ren, LY Zheng, ZF Xia, YM Yao - Frontiers in immunology, 2022 - frontiersin.org
Sepsis represents a life-threatening organ dysfunction due to an aberrant host response. Of
note is that majority of patients have experienced a severe immune depression during and …

Molecular and cellular aspects of sepsis-induced immunosuppression

TS Wang, JC Deng - Journal of molecular medicine, 2008 - Springer
Sepsis is a significant cause of death worldwide. Although the prevailing theory of the sepsis
syndrome has been that of a condition of uncontrolled inflammation in response to infection …

Advances in the understanding and treatment of sepsis-induced immunosuppression

F Venet, G Monneret - Nature Reviews Nephrology, 2018 - nature.com
Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. Sepsis can induce acute kidney injury and multiple organ failures …

The immune system's role in sepsis progression, resolution, and long‐term outcome

MJ Delano, PA Ward - Immunological reviews, 2016 - Wiley Online Library
Sepsis occurs when an infection exceeds local tissue containment and induces a series of
dysregulated physiologic responses that result in organ dysfunction. A subset of patients …