Inflammasomes and the fine line between defense and disease
S Christgen, TD Kanneganti - Current opinion in immunology, 2020 - Elsevier
Highlights•IRF proteins regulate important components of inflammasome activation.•The
NLRP1b inflammasome is activated through 'functional degradation'.•NLRP6 senses …
NLRP1b inflammasome is activated through 'functional degradation'.•NLRP6 senses …
Inflammasome as a promising therapeutic target for cancer
Inflammasomes are the major mechanistic complexes that include members of the NOD-like
receptor (NLRs) or AIM2-like receptors (ALRs) families, which are affiliated with the innate …
receptor (NLRs) or AIM2-like receptors (ALRs) families, which are affiliated with the innate …
Inflammasome complexes: emerging mechanisms and effector functions
VAK Rathinam, KA Fitzgerald - Cell, 2016 - cell.com
Canonical activation of the inflammasome is critical to promote caspase-1-dependent
maturation of the proinflammatory cytokines IL-1β and IL-18, as well as to induce pyroptotic …
maturation of the proinflammatory cytokines IL-1β and IL-18, as well as to induce pyroptotic …
Inflammasomes: mechanism of action, role in disease, and therapeutics
H Guo, JB Callaway, JPY Ting - Nature medicine, 2015 - nature.com
The inflammasomes are innate immune system receptors and sensors that regulate the
activation of caspase-1 and induce inflammation in response to infectious microbes and …
activation of caspase-1 and induce inflammation in response to infectious microbes and …
Mechanistic insights from inflammasome structures
Inflammasomes are supramolecular complexes that form in the cytosol in response to
pathogen-associated and damage-associated stimuli, as well as other danger signals that …
pathogen-associated and damage-associated stimuli, as well as other danger signals that …
The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis
L Franchi, T Eigenbrod, R Muñoz-Planillo… - Nature …, 2009 - nature.com
The inflammasome is a multiprotein complex that mediates the activation of caspase-1,
which promotes secretion of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18 …
which promotes secretion of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18 …
Inflammasomes: mechanisms of action and involvement in human diseases
D Bulté, C Rigamonti, A Romano, A Mortellaro - Cells, 2023 - mdpi.com
Inflammasome complexes and their integral receptor proteins have essential roles in
regulating the innate immune response and inflammation at the post-translational level. Yet …
regulating the innate immune response and inflammation at the post-translational level. Yet …
Recent advances in inflammasome biology
DE Place, TD Kanneganti - Current opinion in immunology, 2018 - Elsevier
Highlights•The NLRP3, NLRC4, and pyrin inflammasomes are regulated by post-
translational modifications.•The Dhx9-NLRP9b inflammasome recognizing viral dsRNA was …
translational modifications.•The Dhx9-NLRP9b inflammasome recognizing viral dsRNA was …
The inflammasome: an integrated view
An inflammasome is a multiprotein complex that serves as a platform for caspase‐1
activation and caspase‐1‐dependent proteolytic maturation and secretion of interleukin‐1β …
activation and caspase‐1‐dependent proteolytic maturation and secretion of interleukin‐1β …
Inflammasomes: mechanism of assembly, regulation and signalling
Inflammasomes are multiprotein signalling platforms that control the inflammatory response
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …