The inflammasome is a cytosolic immune signaling complex that induces inflammation and
pyroptosis. Inflammasome complexes respond to a variety of pathogens, as well as danger …

Specific IL-1 family cytokines are expressed by cells as cytosolic pro-forms that require
cleavage for their activity and cellular release. IL-1β, IL-18, and IL-37 maturation and …

Inflammasomes are a set of intracellular protein complexes that enable autocatalytic
activation of inflammatory caspases, which drive host and immune responses by releasing …

Inflammasomes are multimeric protein complexes that typically comprise a sensor, an
adaptor and the zymogen procaspase-1. An inflammasome assembles in response to a …

Inflammasomes play essential roles in immune protection against microbial infections.
However, excessive inflammation is implicated in various human diseases, including …

Inflammasomes are multiprotein complexes that serve as a platform for caspase-1 activation
and interleukin-1β (IL-1β) maturation as well as pyroptosis. Though a number of …

Inflammasomes are specialized signaling platforms critical for the regulation of innate
immune and inflammatory responses. Various NLR family members (ie, NLRP1, NLRP3 …

Innate immune responses have the ability to both combat infectious microbes and drive
pathological inflammation. Inflammasome complexes are a central component of these …

Inflammasomes are multi-protein complexes that mediate activation of caspase-1, which
promotes secretion of the proinflammatory cytokines interleukin-1β and interleukin-18 and …

The importance of innate immunity lies not only in directly confronting pathogenic and non-
pathogenic insults but also in instructing the development of an efficient adaptive immune …