Myelination-independent functions of oligodendrocyte precursor cells in health and disease

Y Xiao, T Czopka - Nature Neuroscience, 2023 - nature.com
Oligodendrocyte precursor cells (OPCs) are a population of tissue-resident glial cells found
throughout the CNS, constituting approximately 5% of all CNS cells and persisting from …

Emerging roles of oligodendrocyte precursor cells in neural circuit development and remodeling

JA Buchanan, NM da Costa, L Cheadle - Trends in neurosciences, 2023 - cell.com
Oligodendrocyte precursor cells (OPCs) are non-neuronal brain cells that give rise to
oligodendrocytes, glia that myelinate the axons of neurons in the brain. Classically known …

From precursors to myelinating oligodendrocytes: contribution of intrinsic and extrinsic factors to white matter plasticity in the adult brain

JJ Boulanger, C Messier - Neuroscience, 2014 - Elsevier
Oligodendrocyte precursor cells (OPC) are glial cells that metamorphose into myelinating
oligodendrocytes during embryogenesis and early stages of post-natal life. OPCs continue …

Features, fates, and functions of oligodendrocyte precursor cells

RA Hill, A Nishiyama… - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
Oligodendrocyte precursor cells (OPCs) are a central nervous system resident population of
glia with a distinct molecular identity and an ever-increasing list of functions. OPCs generate …

Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function

LA Akay, AH Effenberger, LH Tsai - Genes & development, 2021 - genesdev.cshlp.org
Oligodendrocyte precursor cells (OPCs) are not merely a transitory progenitor cell type, but
rather a distinct and heterogeneous population of glia with various functions in the …

Functionally distinct subgroups of oligodendrocyte precursor cells integrate neural activity and execute myelin formation

R Marisca, T Hoche, E Agirre, LJ Hoodless… - Nature …, 2020 - nature.com
Recent reports have revealed that oligodendrocyte precursor cells (OPCs) are
heterogeneous. It remains unclear whether such heterogeneity reflects different subtypes of …

From neural stem cells to myelinating oligodendrocytes

B Rogister, T Ben-Hur, M Dubois-Dalcq - Molecular and Cellular …, 1999 - Elsevier
The potential to generate oligodendrocytes progenitors (OP) from neural stem cells (NSCs)
exists throughout the developing CNS. Yet, in the embryonic spinal cord, the …

Oligodendrocyte precursor cells as a therapeutic target for demyelinating diseases

SD Skaper - Progress in Brain Research, 2019 - Elsevier
The mechanisms regulating differentiation of multipotent oligodendrocyte progenitor cells
(OPCs) into mature oligodendrocytes (OLs) are critical to our understanding of myelination …

Oligodendroglia and myelin in neurodegenerative diseases: more than just bystanders?

B Ettle, JCM Schlachetzki, J Winkler - Molecular neurobiology, 2016 - Springer
Oligodendrocytes, the myelinating cells of the central nervous system, mediate rapid action
potential conduction and provide trophic support for axonal as well as neuronal …

Oligodendrocyte progenitor cell fate and function in development and disease

BLL Clayton, PJ Tesar - Current opinion in cell biology, 2021 - Elsevier
Differentiation of oligodendrocyte progenitor cells (OPCs) into myelination-capable mature
oligodendrocytes is essential for proper function of the central nervous system. OPCs are …