Cell competition is emerging as a quality control mechanism that eliminates unfit cells in a
wide range of settings from development to the adult. However, the nature of the cells …

Cell competition is emerging as a quality-control mechanism that eliminates unfit cells in a
wide range of settings from development to the adult. However, the nature of the cells …

Ensuring that mutations are not propagated within stem cell populations is key to proper
development and homeostasis. This is especially relevant when it comes to pluripotent cells …

The process of embryonic development involves remarkable cellular plasticity, which
governs the coordination between cells necessary to build an organism. One role of this …

From fertilization until the onset of gastrulation the early mammalian embryo undergoes a
dramatic series of changes that converts a single fertilized cell into a remarkably complex …

A fundamental question in developmental biology is whether there are mechanisms to
detect stem cells with mutations that, although not adversely affecting viability, would …

The mammalian embryo exhibits a remarkable plasticity that allows it to correct for the
presence of aberrant cells, adjust its growth so that its size is in accordance with its …

Stem cells often possess immature mitochondria with few inner membrane invaginations,
which increase as stem cells differentiate. Despite this being a conserved feature across …

Metabolic support was long considered to be the only developmental function of
hematopoiesis, a view that is gradually changing. Here, we disclose a mechanism triggered …

Differentiation of stem/progenitor cells is associated with a substantial increase in
mitochondrial mass and complexity. Mitochondrial dynamics, including the processes of …