Tumor hypoxia has been attributed to play a crucial role in tumorigenesis and therapeutic
resistance. Recently, it has been suggested that hypoxia leads to and maintains the …

In vitro investigations of tumor stem-like cells (TSC) isolated from human glioblastoma (GB)
surgical specimens have been done primarily at an atmospheric oxygen level of 20%. To …

Hypoxia promotes the expansion of non-neoplastic stem and precursor cell populations in
the normal brain, and is common in malignant brain tumors. We examined the effects of …

Glioblastoma multiforme is the most aggressive and malignant primary brain tumour, with a
median survival rate of between 15 to 17 months. Heterogeneous regions occur in …

Objective: To investigate the relationship between hypoxia and in vitro “stemness” of cancer
stem cells (CSCs). Methods: U87 cells, U251 cells and primary glioma cells (n= 3) …

Glioblastoma (GBM) prognosis remains dismal, with most patients succumbing to disease
within 1 or 2 years of diagnosis. Recent studies have suggested that many solid tumors …

Hypoxia contributes to the progression of a variety of cancers by activating adaptive
transcriptional programs that promote cell survival, motility and tumor angiogenesis …

BACKGROUND AND PURPOSE: To identify molecular markers of tumor hypoxia and
potential therapeutic targets in glioblastoma (GBM), we investigated the hypoxia-related …

Traditional studies have shown that transcription factors, including SOX-2, OCT-4, KLF-4,
Nanog and Lin-28A, contribute to the dedifferentiation and reprogramming process in …

Glioblastomas are highly lethal cancers that contain cellular hierarchies with self-renewing
cancer stem cells that can propagate tumors in secondary transplant assays. The potential …